3,6-Dihydroxypyridazine 顺丁烯二酰肼

CAS 123-33-1 MFCD00006665

化学结构图

123-33-1
SMILES: O=c1ccc(=O)[nH][nH]1

化学属性

Mol. FormulaC4H4N2O2
Mol. Weight112.09
Melting Point299-301°C
Density1.6
Flash Point300°C
TSCAYes
Autoignition Point707 °F
Solubility6 G/L
Stability对湿度敏感
Boiling Point209.98 °C at 760 mmHg

别名和识别编码

Chemical Name3,6-Dihydroxypyridazine
Synonym Maleic hydrazide {LY} Maleic hydrazide {} {LY} Maleic hydrazide {} {} {LY} Maleic hydrazide {} {} {} {LY} Maleic hydrazide {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006665
PubChem Substance ID21954
Beilstein Registry Number24,312
CAS Number123-33-1
EC Number204-619-9
Reaxys-RN112223
Merck Number5705
Alfabeta NameDIHYDROPYRIDAZINEDIONE 1236---,,
Chemical Name Translation顺丁烯二酰肼
InChIKeyBGRDGMRNKXEXQD-UHFFFAOYSA-N
Wiswesser Line NotationT6VMMVJ
InChIInChI=1S/C4H4N2O2/c7-3-1-2-4(8)6-5-3/h1-2H,(H,5,7)(H,6,8)
Canonical SMILESO=C1C=CC(NN1)=O
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分类

  • {SNA} 2005/37/EC, Alphabetical Index of Analytical Standards, Analytical Standards, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, H-M, M, MA - MD, Method and Regulation Specific, Plant growth regulators, 农残和代谢标准品, 农残标准品, 分析/色谱, 按照字母排序
  • {SNA} 2005/37/EC, Additional Standards, Analytical Standards, European Community: ISO, DIN and DL 152, H-M, Method and Regulation Specific, Plant growth regulators, 农残和代谢标准品, 农残标准品, 分析/色谱,

产品应用

  • 马来酰肼为选择性除草剂和暂时性植物生长抑制剂。

相关文献及参考

  • Merck: 14,5705 Beilstein:24,312
  • Merck: 14,5705

安全信息

GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P305+P351+P338
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P305+P351+P338+P337+P313
  • P302+P350
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P337+P313
  • P302+P352+P332+P313+P362+P364
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H228 Flammable solid 易燃固体
  • H303 May be harmfully swallowed 吞食可能有害
Hazard Codes Xn Xi,Xn
WGK Germany2
RTECSUR5950000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning {} {} {} {} {TCI}
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
UN Number UN 3077 9/PG 3 3077
Warnings IRRITANT
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2600 mg/kg/65W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   19,392,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >20 gm/m3
TOXIC EFFECTS :
   Details

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,526,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,526,1991

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/disc
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 21,319,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,249,1979

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Scien

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 24,460,1986

TYPE OF T

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 344,41,1995

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4000 ppm
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 207,439,1965

其他信息

  • Acros Organics:马来酰肼 3,6-Dihydroxypyridazine, 99%(123-33-1)
  • 可燃性危险特性:燃烧产生有毒氮氧化物气体
  • 毒性分级:中毒
  • 方法二:由顺丁烯二酸酐与水合肼反应而得。在反应锅中投入水及40%水合肼,搅拌冷却下滴加30%盐酸,温度控制在20℃以下,至pH值为6.2-6.4,投入顺丁烯二酸酐,缓缓升温至106-110℃,回流2h,降温至5℃,甩滤,滤饼用冰水洗至pH4.8-5.1,干燥,得顺丁烯二酰肼,收率97%。
  • TCI Shanghai:顺丁烯二酸肼 Maleic Hydrazide,>;98.0%(LC)(T)(123-33-1)
  • 顺丁烯二酰肼价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30111424 顺丁烯二酰肼 25g 35元 2011/08/23 30111460 顺丁烯二酰肼 25g
  • 注意事项:[1]本品喷洒过的作物、饲料不能喂饲牲畜,喷洒区内不能放牧。 [2]应贮存于阴凉干燥处
  • 灭火剂:干粉、泡沫、砂土
  • MOL 文件:123-33-1.mol
  • MSDS 信息:马来酰肼(123-33-1).msds
  • 下游产品:3,6-二氯哒嗪 --> 磺胺二甲基嘧啶
  • Sigma Aldrich:123-33-1(sigmaaldrich)
  • 方法一:由丁烯二酸酐(或丁二烯二酸)与硫酸肼于35~56℃下反应制得。
  • 毒性:大鼠急性经口LD 50 1400mg/kg,其钠盐为6950mg/kg,二乙醇盐为2340mg/kg。无刺激作用。用含5%原药的饲料喂养大鼠2年未出现中毒症状,未见致畸、致癌、致突变性。对鱼低毒,鲈鱼LC 50 75mg/L。对蜜蜂无毒。
  • 海关编码:29339990
  • 微溶于冷水,溶于热水、热碱液,不溶于醚、氯仿。
  • 上游原料:水合肼 --> 水合肼 --> 马来酸酐
  • 外观性质:白色结晶体。
  • Alfa Aesar:马来酰肼,97% Maleic hydrazide, 97%(123-33-1)
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 用途三:植物生长调节剂。通过叶面或根部吸入,由木质部和韧皮部传导,抑制细胞分裂而抑制植物生长。0.1%~0.05%药液可防除禾草和草坪、果园及水边杂草;0.025%药液抑制洋葱和马铃薯贮存期发芽;0.1%~0.05%药液抑制及延缓烟草侧芽生长和保持柑橘苗免受霜害。
  • 用途四:顺丁烯二酰肼为选择性除草剂和暂时性植物生长抑制剂。药剂可通过叶面角质层进入植株,降低光合作用、渗透压和蒸发作用,能强烈地抑制芽的生长。用于防止土豆、洋葱、大蒜和萝卜贮藏期发芽,并有抑制作物生和延长开花的作用,也可用于非耕地除草。该品的互变异构为3,6-二羟基哒嗪(3,6-Dihydroxypyridazine)。是磺胺类药物磺胺甲氧嗪的中间体。
  • 类别:农药
  • 用途五:顺丁烯二酰肼为选择性除草剂和暂时性植物生长抑制剂。药剂可通过叶面角质层进入植株,降低光合作用
  • 用途六:暂时性植物生长抑制剂。选择性除草剂(能除去马唐草)。防止贮藏中的洋葱、土豆和胡萝卜发芽。园艺与农业实验。 顺丁烯二酰肼为选择性除草剂和暂时性植物生长抑制剂。药剂可通过叶面角质层进入植株,降低光合作用、渗透压和蒸发作用,能强烈地抑制芽的生长。用于防止土豆、洋葱、大蒜和萝卜贮藏期发芽,并有抑制作物生和延长开花的作用,也可用于非耕地除草。该品的互变异构为3,6-二羟基哒嗪(3,6-Dihydroxypyridazine)。是磺胺类药物磺胺甲氧嗪的中间体。
  • 检测方法:HPLC
  • 图谱信息:顺丁烯二酰肼(123-33-1)红外图谱(IR2) 顺丁烯二酰肼(123-33-1)核磁图( 13 CNMR) 顺丁烯二酰肼(123-33-1)红外图谱(IR1

系列性分类


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