Morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl-

CAS 125-29-1 MFCD00661056

化学结构图

125-29-1
SMILES: COc1ccc2c3c1OC1C(=O)CCC4C(C2)N(C)CCC314

化学属性

Mol. FormulaC18H21NO3
Mol. Weight299.40

别名和识别编码

Chemical NameMorphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl-
CAS Number125-29-1
Synonym 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one DICO (5?)- Bekadid 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan Hydrocodone Dicodid Multacodin Dihydrocodeinone
Wiswesser Line NotationT B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1
Beilstein Registry Number0094193
PubChem Substance ID5284569
InChIInChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Analgesic (narcotic); antitussive.

相关文献及参考

  • Eddy, N.B., et al.: J. Pharmacol. Exp. Ther., 52, 468 (1934),
  • Stein, A., et al.: Pharmazie, 10, 180 (1955),

安全信息

Restrict 精麻类化学品 {} 麻醉药品
RTECSQD2800000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,238,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 86 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 52,468,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 194,296,1940

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 194,296,1940

系列性分类

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