(+-)-METHADONEHYDROCHLORIDE--DEA 中文名称暂缺

CAS 125-56-4 MFCD N/A

化学结构图

125-56-4
SMILES: CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1.Cl

化学属性

Mol. FormulaC21H27NO.ClH
Mol. Weight345.95

别名和识别编码

Chemical Name3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-,hydrochloride, (+-)-
Chemical Name Translation中文名称暂缺
Chemicalbook IDCB7498235
Wiswesser Line Notation2VXR&R&Y2&N1&1
Synonym Ketalgin hydrochloride Dolophin hydrochloride Heptadon hydrochloride Moheptan Dolophine hydrochloride AN-148 Butalgin dl-Amidone hydrochloride Physeptone hydrochloride dl-Methadone hydrochloride Racemic methadone hydrochloride Amidon hydrochloride Algolysin Fenadone Phenadone hydrochloride Miadone Macodin 1,1-Diphenyl-1-(2-dimethylaminopropyl)-2-butanone hydrochloride, (+-)- Diaminon hydrochloride dl-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride Polamidon (+-)-Methadone hydrochloride Tussal Depridol Hoechst 10,820 4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochloride (+-)- Algidon Mephenon Adanon hydrochloride
CAS Number125-56-4
PubChem Substance ID14184
InChIInChI=1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10950 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   11,640,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11680 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   11,640,1988

RTECSMJ6130000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 92,269,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 95400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOCEAH Journal of Organic Chemistry.  (American Chemical Soc., Distribution
   Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)  V.1-
   1936-  Volume(issue)/page/year: 17,321,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7601 ug/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 145,11,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 98,305,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 13 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 253,202,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 123 mg/kg
SEX/DURATION            : female 2 week(s) pre-mating  - 2 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 164,275,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 mg/kg
SEX/DURATION            : lactating female 21 day(s)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 mg/kg
SEX/DURATION            : lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NTOTDY Neurobehavioral Toxicology and Teratology.  (Fayetteville, NY) V.3-8,
   1981-86.  For publisher information, see NETEEC. Volume(issue)/page/year:
   4,455,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

系列性分类

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