Dextrorphan
CAS 125-73-5 MFCD00864199
化学结构图
SMILES: CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc1ccc(O)cc13
化学属性
| Mol. Formula | C18H25NO |
|---|---|
| Mol. Weight | 271.40 |
| Melting Point | >=195 °C |
别名和识别编码
| Chemical Name | Dextrorphan |
|---|---|
| Synonym | (+)-cis-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol (+-)-17-Methylmorphinan-3-ol 2H-10,4a-(Iminoethano)phenanthren-6-ol, Dextrorphan {} {} {} {} {} {} {} {} {} {} {hazard_com} d-3-Hydroxy-N-methylmorphinan |
| MDL Number | MFCD00864199 |
| PubChem Substance ID | 5360697 |
| EC Number | 204-754-3 |
| Wiswesser Line Notation | T6 G666/FQ 2AF Q FX ONT&TTJ IQ O1 -(+) |
| CAS Number | 125-73-5 |
| Beilstein Registry Number | 0088093 |
| InChI | InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1 |
| Chemical Name Translation | |
| Canonical SMILES | OC1=CC=C2[C@@H]3C([H])[C@]4(C)CCCC[C@@]4(CCN3C)C2=C1 |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, D-DIF, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 131 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 22,1370,1957
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 276 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 22,1370,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 584 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Skin and Appendages - hair REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,1188,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 25750 ug/kg SEX/DURATION : female 5-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 200,255,1977
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