demeclocycline 地美环素

CAS 127-33-3 MFCD00127333

化学结构图

127-33-3
SMILES: CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@@H]12

化学属性

Mol. FormulaC21H21ClN2O8
Mol. Weight464.89

别名和识别编码

Chemical Name2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-1,11-dioxo-
Chemical Name Translation地美环素
Chemicalbook IDCB5918843
Wiswesser Line NotationL E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ OGRQ
Synonym Demeclor 6-Demethylchlortetracycline Demethylchlorotetracycline Bioterciclin Chlortetracycline, 6-demethyl- Diuciclin Tetracycline, 7-chloro-6-demethyl- 6-Demetil-7-clorotetraciclina Perciclina 6-Demethyl-7-chlortetracycline 6-Demethyl-7-chlorotetracycline 7-Chloro-6-demethyltetracycline Novotriclina Demeclocycline DMCT Deganol Ledermycin Clortetrin Tri-demethylchlortetracycline Demetraclin Demethylchlortetracycline RP 10192 Demethylchlortetracyclin Sumaclina Demethylchlortetracycline base 6-Demethylchlorotetracycline
CAS Number127-33-3
PubChem Substance ID54680690
InChIInChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-27,30,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1
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安全信息

RTECSQI7650000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 358 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 68 mg/kg/8D
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   CTCEA9 Current Therapeutic Research, Clinical & Experimental.  (Therapeutic
   Research Press, Inc., POB 514, Tenafly, NJ 07670)  V.1-    1959-
   Volume(issue)/page/year: 15,734,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 129,350,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,281,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSER

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 3750 ug/L
REFERENCE :
   BCPHBM British Journal of Clinical Pharmacology.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK)  V.1-    1974-  Volume(issue)/page/year:
   16,127,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 240 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   188,178,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 gm/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   AJOMAZ Alabama Journal of Medical Sciences.  (Univ. of Alabama Medical
   Center, Univ. Station, Birmingham, AL 35294)  V.1-25, 1964-88.
   Volume(issue)/page/year: 10,89,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 gm/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   AJOMAZ Alabama Journal of Medical Sciences.  (Univ. of Alabama Medical
   Center, Univ. Station, Birmingham, AL 35294)  V.1-25, 1964-88.
   Volume(issue)/page/year: 10,89,1973

系列性分类

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