Sodium saccharine 糖精钠

CAS 128-44-9 MFCD00013092

化学结构图

128-44-9
SMILES: O=C1[N-]S(=O)(=O)c2ccccc21.[Na+]

化学属性

Mol. FormulaC7H4NNaO3S
Mol. Weight205.17
Appearance 无色至白色斜方晶系板状结晶或白色结晶性风化粉末。无臭或有轻微气味。昧极甜，即使在10000倍的水溶液中仍有极强甜昧，甜味阈值约0.00048%。在稀溶液中的甜度约为蔗糖的500倍。浓度稀时呈甜味，浓时(大于0.026%)有苦味，故单独使用时的浓度应低于0.02%。在酸性条件下加热，甜味消失。并可形成苦昧的邻氨基磺酰苯甲酸。易溶于水(1g/1.5m1)，微溶于乙醇(1g/50m1)。
SolubilityH2O: 1 M at 20 °C, clear, colorless
Melting Point>300 °C

别名和识别编码

Chemical NameSodium saccharine
CAS Number128-44-9
Reaxys-RN3599229
Beilstein Registry Number27,170
PubChem Substance ID656582
MDL NumberMFCD00013092
Chemical Name Translation糖精钠
Synonym Saccharin (sodium) {LY} Saccharin (sodium) {} {LY} Saccharin (sodium) {} {} {LY} Saccharin (sodium) {} {} {} {LY} Saccharin (sodium) {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Saccharin (sodium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number204-886-1
Wiswesser Line NotationT56 BSWMVJ &-NA-
LabNetwork Molecule IDLN00201348
InChIInChI=1S/C7H5NO3S.Na/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;/h1-4H,(H,8,9);/q;+1/p-1
Canonical SMILESO=C(C1=CC=CC=C12)N([Na])S2(=O)=O
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分类

  • {Chemicalbook} 食品添加剂: 调味剂（风味增强剂）: 甜味剂

安全信息

RTECSDE4550000
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
WGK Germany2 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 176 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/p

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1827 gm/kg/87W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   52,113,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 112 gm/kg/8W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,2943,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1190 gm/kg/85W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Kidney, Ureter, Bladder - changes in blood vessels or in circulation of
   kidney
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG2

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 6,313,1968

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,1367,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 6,313,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 6,313,196

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg/60H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 32,81,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 8 gm/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 62 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 32,81,1975

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 11 gm/L/4H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-

{hazard_com

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 32,81,1975

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 32,81,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 325 gm/kg
SEX/DURATION            : male 4 week(s) pre-mating
                          female 4 week(s) pre-mating  - 4 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   29,657,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 gm/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(4),1047,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 gm/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 19,267,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 gm/kg
SEX/DURATION            : lac

其他信息

  • 用途二:无营养甜味剂。
  • 下游产品:氯嘧黄隆 --> 吡罗昔康
  • 用途一:用作食品甘味剂及诊断用药
  • MSDS 信息:Sodium 1,2-benzisothiasolin-3-one-1,1-dioxide(128-44-9).msds
  • 方法一:由甲苯与氯磺酸进行氯磺化作用，得油状的邻甲苯磺酰氯和副产品结晶状对甲苯磺酰氯，分离后与氨作用并氧化后得糖精，再经氢氧化钠碱化而成。 余见“02331”。
  • 含量分析:精确称取预经干燥的试样0.3g，溶于20ml冰醋酸中。加结晶紫试液(TS-74)2滴作为指示剂，用0.1mol/L高氯酸滴定，当溶液的呈色由紫经蓝变青时作为滴定终点。同时进行空白对照试验，尽量排除不必要的误差。每mI0.1mol/L高氯酸相当于糖精(C7H4NNaO3S)20.52mg。
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 糖精钠 新型豆制品（大豆蛋白膨化食品、大豆素肉等） 甜味剂 1.0 糖精钠 果酱 甜味剂 0.2
  • 使用限量:GB 2760—2002(g/kg)：饮料、酱菜类、复合调味料、蜜饯、配制酒、雪糕、冰淇淋、冰棍、糕点、饼干、面包，0.15；瓜子，1.2；干果、果仁、五香豆、炒豆类，1.0；话李、话杏、甘草橄榄、甘草金柑、芒果干、无花果干、话梅、陈皮、杨梅干，5.0。 FEMA(mg/kg)：软饮料72；冷饮150；糖果2100～2600；焙烤食品12。 FDA，§180．37(2000)：饮料、果汁、固体饮料，12mg/28.41m1液体，甜度相当于一汤匙的量为20mg；每一份规定大小的加工食品为30mg。 USDA，9CFR，§318．7(2000)：扎肉(培根)0.01%。
  • 鉴别试验:其中： 1、2、3条与“糖精铵(02302)”中鉴别试验法1、2、3条相同。 易溶于水(1g/1.5m1)，略溶于乙醇(1g/50m1)。按OT-42方法测定。 2g试样的灼烧残渣，其钠盐试验阳性(IT-28)。
  • Sigma Aldrich:128-44-9(sigmaaldr
  • FEMA:2997
  • 上游原料:氢氧化钠 --> 盐酸 --> 甲醇 --> 硫酸 --> 亚硝酸钠 --> 氢氧化铵 --> 氯磺酸 --> 次氯酸钠 --> 苯酐 --> 4-甲苯磺酰氯 --> 二氧化硫 --> 糖精 --> 邻甲苯磺酰胺 --> 邻甲苯磺酰氯
  • TCI Shanghai:1,1-二氧代-1,2-苯并异噻唑-3(2H)-酮钠盐二水合物 o-Sulfobenzimide Sodium Salt Dihydrate,>;98.0%(LC)(T)(128-44-9)
  • 糖精钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B0131 邻苯甲酰磺酰亚胺钠盐二水合物 o-Sulfobenzimide Sodium Salt Dihydrate 500G 927元 2014/06/02 B0131 邻苯甲酰磺酰亚胺钠盐二水合物 o-Sulfobenzimide Sodium Salt Dihydrate 25G 248元
  • MOL 文件:128-44-9.mol
  • 参考质量标准:指标名称 FAO/WHO,1998 GB 4578-84(强制性国标) 含量(无水基计) 98%～101% 99.0% 干燥失重(120℃，4h) ≤15% ≤15% 苯甲酸盐和水杨酸盐试验 阴性 - 易碳化物试验 正常 - 酸度和碱度试验 正常 - 甲苯磺酰胺(以NH4 + 计) ≤25mg/kg ≤0.0025% 硒(GT-28) ≤30mg／kg - 砷(GT-3) ≤3mg/kg ≤0.0002% 重金属(GT-16-2) ≤10mg/kg ≤0.001% 铵盐(NH4 + 计) - ≤0.0025%
  • 毒性:ADI 0～5mg/kg(ADI指糖精及其钙、钾、钠盐之和；FAO/WHO，2001)。 LD 50 17.5g/kg(小鼠，经口)。 有长期服用导致膀胱癌的报道，但有争论。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Metal Compounds 金属化合物

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