Lidocaine 利多卡因

CAS 137-58-6 MFCD00026733

化学结构图

137-58-6
SMILES: CCN(CC)CC(=O)Nc1c(C)cccc1C

化学属性

Mol. FormulaC14H22N2O
Mol. Weight234
Melting Point66.0 to 70.0 deg-C
SolubilityDMSO 47 mg/mL Water 9 mg/mL Ethanol 47 mg/mL
Boiling Point182°C/4mmHg(lit.)

别名和识别编码

Chemical NameLidocaine
CAS Number137-58-6
Alfabeta NameDIMETHYLPHENYLDIETHYLGLYCINAMIDE NNN12622()----,,
MDL NumberMFCD00026733
Synonym Diethylaminoacet-2,6-xylidide 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide Lignocaine Xylocaine 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide omega-Diethylamino-2,6-dimethylacetanilide alpha-Diethylaminoaceto-2,6-xylidide alfa-Dietilamino-2,6-dimetilacetanilide Lignocaine Diethylaminoaceto-2,6-xylidide Xylestesin Duncaine Maricaine Lidocaine 2-(Diethylamino)-2',6'-acetoxylidide 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide Xylocain Solcain Rucaina alpha-Diethylamino-2,6-acetoxylidide Xilocaina Lida-mantle alpha-Diethylamino-2,6-dimethylacetanilide
PubChem Substance ID87572107
EC Number205-302-8
Beilstein Registry Number12(4)2538
Reaxys-RN2215784
Chemical Name Translation利多卡因
Merck Number5482
Wiswesser Line Notation2N2&1VMR B1 F1
LabNetwork Molecule IDLN00157807
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分类

  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Analgesic, Analytical Standards, Analytical/Chromatography, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chromatography, Doping Substances, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, Horse Doping Drugs, Inhibitors, Ion Channels, L, Lidocaine, Monovalent Ion Channels, Other Sodium Channel Modulators, Pharmaceutical Standards, Sodium Channel Modulators,
  • {SNA} Bioactive Sm

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSAN7525000
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S22 Do not breathe dust 不要吸入粉尘;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P307+P311
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P302+P352+P333+P313+P362+P364
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P405 Store locked up. 上锁保管。
  • P308+P313
  • P301+P312+P330
  • P308+P311
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
Storage condition 储存温度-20°C
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1700 ug/kg/2M-C
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 4,143,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 8643 ug/kg/4H-C
TOXIC EFFECTS :
   Behavioral - toxic psychosis
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   97,149,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 300 mg/kg/5D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   PECAE5 Pediatric Emergency Care.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1985-  Volume(issue)/page/year: 10,344,1994

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 41 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   31,273,1972

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 umol/plate
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 34,157,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 mg/kg
SEX/DURATION            : female 3-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 33,73C,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   11,395,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NTOTDY Neurobehavioral Toxicology and Teratology.  (Fayetteville, NY) V.3-8,
   1981-86.  For publisher information, see NETEEC. Volume(issue)/page/year:
   8,61,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE                    : 540 ug/kg
SEX/DURATION            : female 39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   ADCHAK Archives of Disease in Childhood.  (Britis

其他信息

  • Lidocaine

系列性分类


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