Fluoroacetic acid 叔丁醇*FYS

CAS 144-49-0 MFCD00039529

化学结构图

144-49-0
SMILES: O=C(O)CF

化学属性

Mol. FormulaC2H3FO2
Mol. Weight78.04
Melting Point33 ºC
Boiling Point165 ºC
Solubility溶于水、乙醇。

别名和识别编码

Chemical NameFluoroacetic acid
Synonym fluoroethanoic acid MFA 氟醋酸FLUOROETHANOICACID α-Fluoroacetic acid 一氟乙酸 Monofluorazijnzuur cymonicacid Fluoroethanoic acid Fluoroacetate HFA Acide-monofluoracetique 2-Fluoroacetic acid Fluoressigsäure Monofluoroacetic acid fluoro-acetic acid RARECHEM AL BO 1262 Gifblaar poison 氟乙酸 fluoroacetic acid fluoro-aceticaci Monofluoressigsaure Cymonic acid 2-fluoroaceticacid 氟醋酸 acide-monofluoracetique(french) acidomonofluoroacetio fluoroacetic Acetic acid, fluoro- fluoroacetate Acido monofluoroacetio alpha-fluoroaceticacid CH2FCOOH Monofluoroacetate 一氟醋酸 FLUOROACETIC ACID acidomonofluoracetio
EC Number205-631-7
CAS Number144-49-0
MDL NumberMFCD00039529
Chemical Name Translation叔丁醇*FYS
Wiswesser Line NotationQV1F
Beilstein Registry Number1739053
PubChem Substance ID5237
InChIInChI=1S/C2H3FO2/c3-1-2(4)5/h1H2,(H,4,5)
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分类

  • {uni_hamburg} no charge; carboxylic acid; 1fragment
  • {SNA} Alkyl Fluorinated Building Blocks, Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks

相关文献及参考

  • Short: II/25B Title: Structure Data Of Free Polyatomic Molecules: Molecules containing One or Two Carbon Atoms Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N. Editor: Kuchitsu, K. Source: Landolt-Börnstein, New Series Volume: II/25B Year: 1999 Keyword: Free Polyatomic Molecules; Carbon Atoms; Molecules ISBN: 3-540-63645-5 ISBN: 978-3-540-63645-8 Internet Resource: DOI:10.1007/b68834 RefComment: IX, 512 pages. Hardcover Abstract: Volume II/25 is a supplemented and revised edition of the preceding volumes II/7, II/15, II/21 and II/23 containing up to date information on inorganic and organic polyatomic molecules. All experimental methods for the determination of quantitative structural data of free molecules have been considered: microwave, infrared, Raman, electronic and photoelectron spectroscopy as well as electron diffraction. The data obtained by these methods have been critically evaluated and compiled. They are presented separately for each molecule, together with a schematic figure of the structure and the original literature.
  • Short: II/4 Title: Molecular Constants from Microwave Spectroscopy Author: Starck, B. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/4 Page: 1-225 Year: 1967 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-03896-5 ISBN: 978-3-540-03896-2 Internet Resource: DOI:10.1007/b19949 RefComment: 67 figs., X
  • Short: II/6 Title: M
  • Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-11365-2 Internet Resource: DOI:10.1007/b19966 RefComment: 196 figs., XI

安全信息

Packing GroupI
Hazard Codes T+,N
Hazard Class6.1(a)
UN Number 2642
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R28 Very toxic if swallowed 吞咽极毒
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R35 Causes severe burns 会导致严重灼伤
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Restrict 剧毒化学品
Warnings 危化品目录(2015) 危险化学品
RTECSAH5950000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4680 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   13,189,1968

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,274,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 250 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 158,382,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Vo

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 468 ug/kg
TOXIC EFFECTS :

GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Signal word Danger

其他信息

  • 外观性质:无色或白色结晶固体。
  • 毒性分级:剧毒
  • 可燃性危险特性:可燃; 受热分解有毒氟化物气体
  • 用途一:直接应用很少。主要用其钠盐为杀鼠药(大白鼠口服LD50 220μg/kg,皮下注射LD50 5mg/kg。对人及家禽、牲畜均有毒)。其酯类如氟乙酸甲酯,田鼠经口LD50 6-10mg/kg,氟乙酸乙酯也有相同的毒性。
  • 类别:腐蚀物品
  • Sigma Aldrich:144-49-0(sigmaaldrich)
  • 储运特性:库房通风低温干燥; 与氧化剂、碱类分开存放。
  • MOL 文件:144-49-0.mol
  • 上游原料:氟乙酸钠
  • 职业标准:TLV-TWA 2 PPM (6 毫克/ 立方米); STEL 15 PPM (45 毫克/ 立方米)
  • MSDS 信息:氟乙酸(144-49-0).msds
  • 急性毒性:口服- 大鼠 LD50: 4.68 毫克/ 公斤; 口服- 小鼠 LD50: 7 毫克/ 公斤
  • 方法一:1.用氯乙酸为原料,以氟化钾与之反应制取;2.以工业生产的氟乙酸钠与硫酸混合蒸馏而得。
  • 灭火剂:砂土、泡沫、雾状水、二氧化碳

系列性分类


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