2-((Naphthalen-1-Yloxy)Methyl)Oxirane 3-(1-萘氧基)-1,2-环氧丙烷

CAS 2461-42-9 MFCD00055643

化学结构图

2461-42-9
SMILES: c1ccc2c(OCC3CO3)cccc2c1

化学属性

Mol. FormulaC13H12O2
Mol. Weight200.25
Boiling Point163-167

别名和识别编码

Chemical Name2-((Naphthalen-1-Yloxy)Methyl)Oxirane
CAS Number2461-42-9
Synonym ######## (1-Naphtyl)glycidyl ether 1-(2,3-epoxypropoxy)-naphthalen 1-(ALPHA-NAPHTHALENOXY)-2,3-EPOXYPROPANE 1-NAPHTHOL GLYCIDYL ETHER 1-Naphthol glycidyl ether 1-Naphthyl glycidyl ether 1-Naphtylglycidyl ether 1-naphthylglycidylether 2-[(1-NAPHTHYLOXY)METHYL]OXIRANE 3-(1-NAPHTHALENYLOXY)-1,2-CYCLOPROPANE(NAFTOPIDIL INTERMEDIATE) 3-(1-Naphthalenyloxy)-1,2-Cycl 3-(1-Naphthoxy)-1,2-Epoxypropane A-NAPHTHYL GLYCIDYL ETHER ALPHA-NAPHTHYLGLYCIDYLETHER Ether, 2,3-epoxypropyl 1-naphthyl Glycidyl 1-naphthyl ether Glycidyl naphthyl ether NAPHTHYL GLYCIDYL ETHER Naphthyl Glycidyl Ethe Oxirane, ((1-naphthalenyloxy)methyl)- [(1-Naphthalenyloxy)methyl]oxirane alpha
MDL NumberMFCD00055643
EC Number219-555-7
Chemical Name Translation3-(1-萘氧基)-1,2-环氧丙烷
Beilstein Registry Number0160552
PubChem Substance ID91521
InChIInChI=1S/C13H12O2/c1-2-6-12-10(4-1)5-3-7-13(12)15-9-11-8-14-11/h1-7,11H,8-9H2
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分类

  • Aromatics
  • Heterocycles
  • Intermediates,

产品应用

  • Used in the preparation of Naftopidil (N213500).

相关文献及参考

  • Erhard, P., et al.: J. Med. Chem., 25, 1402

安全信息

RTECSQJ6873000
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 299,19,1993

TYPE OF TEST            : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   22,71,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,115,1988

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 224,253,1989

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 224,253,1989

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H351 Suspected of causing cancer 怀疑致癌
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P333+P313
  • P337+P313
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 方法一:将α-萘酚与环氧氯丙烷加热反应,醚化后生成1-氯-3-(1-萘氧基)-2-丙醇,然后在氢氧化钠作用下脱除氯化氢得到该品。
  • 上游原料:环氧氯丙烷 --> a-萘酚
  • MOL 文件:2461-42-9.mol
  • 用途一:心得安的中间体。

系列性分类


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