(2S,3S)-2,3-Dihydroxybutane-1,4-Diyl Dimethanesulfonate (2S,3S)-2,3-二羟基丁烷-1,4-二基二甲基磺酸酯

CAS 299-75-2 MFCD01679769

化学结构图

299-75-2
SMILES: CS(=O)(=O)OC[C@@H](O)[C@H](O)COS(C)(=O)=O |&1:6,8|

化学属性

Mol. FormulaC6H14O8S2
Mol. Weight278.32

别名和识别编码

Chemical Name(2S,3S)-2,3-Dihydroxybutane-1,4-Diyl Dimethanesulfonate
Wiswesser Line NotationWS1&O1YQYQ1OSW1
Synonym 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))- Tresulfan NSC-39069 Treitol, 1,4-dimethanesulfonate, (2S,3S)- CB 2562 Treosulphan Treosulfan
CAS Number299-75-2
Chemical Name Translation(2S,3S)-2,3-二羟基丁烷-1,4-二基二甲基磺酸酯
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安全信息

RTECSXO8500000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 222 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - leukopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,203,1965

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 222 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - agranulocytosis
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,203,1965

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 300 mg/kg/2D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 234,135,1990

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 160 mmol/L
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 160,228,1969

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 4500 ug/L
REFERENCE :
   EJCODS European Journal of Cancer and Clinical Oncology.  (Pergamon Press,
   c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)  V.17(7)-
   25, 1981-89.  For publisher information, see EJCAEL Volume(issue)/page/year:
   18,979,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   21,95,1993

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 234,135,1990

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Pare

系列性分类

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