Methamphetamine hydrochloride, (dl)

CAS 300-42-5 MFCD00069952

化学结构图

300-42-5
SMILES: CNC(C)CC1CCCCC1.Cl

化学属性

Mol. FormulaC10H15N.ClH
Mol. Weight185.72

别名和识别编码

Chemical NamePhenethylamine, N,alpha-dimethyl-, hydrochloride
CAS Number300-42-5
Synonym Depoxin Doxephrin Madrine Desfedrin N-Methyl-beta-phenylisopropylaminhydrochlorid Norodrin Corvitin Amedrine Obesin Doxephin (±)-1-苯基-2-甲氨基丙烷 (±)-甲基苯丙胺 Phedrisox Detrex Noradrin Dopidrin Psykoton C 6379 Daropervamin Psicopan 914F Miller drine Lanazine Metanfetamina Oxydrene Fenyprin Premodrin Des-oxa-D Methampex Phedoxe Methamphin Metamsustac Oxyfed Metamfetamina Oxydrin Desoxyephedrine hydrochloride Semoxydrine Methylbenzedrin Pisichergina Psiquergina Methedrinal Kemodrin Normadrine N,alpha-Dimethylphenethylamine hydrochloride 2-Methylamino-1- DEA oxo-5 Psychergine N,?-Dimethylbenzeneethanamine Hydrochloride Neopharmedrine Levetamin Estimulex Bombita Desfedran Dexophrine Desamine Neodrine Psichergina Mepho-D Desossiefedrina Oxydess Desoxedrine Amphedroxyn Amphedroxy Benzeneethanamine, N,alpha-dimethyl-, hydrochloride Amdram Methoxyn Deoxyephedrine Metamphetamin Methylpropamine
MDL NumberMFCD00069952
EC Number206-093-6
InChIKeyTWXDDNPPQUTEOV-UHFFFAOYSA-N
Wiswesser Line Notation1MY1&1R &GH
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,
  • {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, D, DA - DH

产品应用

  • A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity.

相关文献及参考

  • Lands, M., et al.: J. Pharmacol. Exp. Ther., 89, 382 (1947),
  • Repke, D.B., et al.: J. Pharm. Sci., 67, 1167 (1978),
  • Pope, H.G., et al.: J. Clin. Psychiatry, 47, 339 (1986),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H300 Fatal if swallowed 吞食致命
RTECSSH5075000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 158,115,1967

{hazard_com

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 158,115,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   PSCHDL Psychopharmacology (Berlin).  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.47-    1976-
   Volume(issue)/page/year: 109,255,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 156 mg/kg
SEX/DURATION            : female 7-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   85,79,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 42 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   DEPBA5 Developmental Psychobiology.  (John Wiley & Sons, Inc., 605 Third
   Ave., New York, NY 10158) V.1-    1968-  Volume(issue)/page/year: 8,397,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 42 mg/kg
SEX/DURATI

系列性分类

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