2-(Furan-2-yl)-3-(5-nitrofuran-2-yl)acrylamide 呋喃基呋喃酰胺

CAS 3688-53-7 MFCD00869231

化学结构图

3688-53-7
SMILES: NC(=O)/C(=C\c1ccc([N+](=O)[O-])o1)c1ccco1

化学属性

Mol. FormulaC₁₁H₈N₂O₅
Mol. Weight248.19
Melting Point>152°C (dec.)
Boiling Point
Flash Point-

别名和识别编码

Chemical Name2-(Furan-2-yl)-3-(5-nitrofuran-2-yl)acrylamide
Chemical Name Translation呋喃基呋喃酰胺
Wiswesser Line NotationT5OJ BYVZU1- BT5OJ ENW
Synonym 2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide 2-(2-Furyl)-3-(5-nitro-2-furyl)acrylic acid amide 2-Furanacetamide, alpha-((5-nitro-2-furanyl)methylene)- 2-Furanacrylamide, alpha-2-furyl-5-nitro- AF 2 (Preservative) AF-2 FF Furylamide Furylfuramide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number3688-53-7
LabNetwork Molecule IDLN04624173
Canonical SMILES-
MDL Number-
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安全信息

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
   Skin and Appendages - tumors
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 1,11,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 127 gm/kg/94W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  Fo

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32400 mg/kg/72W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (100),80,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 211 gm/kg/63W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Blood - leukemia
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   68,825,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

RTECSAS3500000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1554 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TJEMAO Tohoku Journal of Experimental Medicine.  (Maruzen Co. Ltd., Export
   Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan)  V.1-    1920-
   Volume(issue)/page/year: 103,331,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 221 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NEZAAQ Nippon Eiseigaku Zasshi.  Japanese Journal of Hygiene.  (Nippon Eisei
   Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606,
   Japan)  V.1-    1946-  Volume(issue)/page/year: 28,463,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 3200 nmol/L
REFERENCE :

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Mammary gland
DOSE/DURATION           : 10 umol/L
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581

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TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Mammary gland
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   45,161,1975

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,1,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 20 ng/disc
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Fish - not otherwise specified
DOSE/DURATION           : 5 mg/L/10D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 31,265,1975

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 2,149,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5750 mg/kg
SEX/DURATION            : male 5 week(s) pre-mating
                          female 5 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - physical
REFERENCE :
   SKEZAP Shokuhin Eiseigaku Zasshi.  Food Hygiene Journal.  (Nippon Shokuhin
   Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
   150, Japan)  V.1-    1960-  Volume(issue)/page/year: 18,455,1977

Storage condition +4 4 4°C, Light sensitive, Light sensitive

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