Quinoline, 6-chloro-4-nitro-, 1-oxide

CAS 3741-12-6 MFCD01685624

化学结构图

3741-12-6
SMILES: O=[N+]([O-])c1cc[n+]([O-])c2ccc(Cl)cc12

化学属性

Mol. FormulaC9H5ClN2O3
Mol. Weight224.61

别名和识别编码

Chemical NameQuinoline, 6-chloro-4-nitro-, 1-oxide
InChIKeyWJRQJTJYCZGDBW-UHFFFAOYSA-N
Wiswesser Line NotationT66 BNJ BO ENW HG
Synonym 6-Chloro-4-nitroquinoline 1-oxide
CAS Number3741-12-6
Beilstein Registry Number0199266
PubChem Substance ID77339
InChIInChI=1S/C9H5ClN2O3/c10-6-1-2-8-7(5-6)9(12(14)15)3-4-11(8)13/h1-5H
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg/50D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   16,631,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38 mg/kg/17W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   53,167,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 43 mg/kg/7W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   49,33,1958

RTECSVB3675000 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 25 umol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 198,195,1963

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Ascites tumor
DOSE/DURATION           : 10 nmol/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   17,31,1975

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 229,416,1971

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,521,1975

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 4 umol/L
REFERENCE :
   PJACAW Proceedings of the Japan Academy.  (Tokyo, Japan)  V.21-53, 1945-77.
   For publisher information, see PJABDW.  Volume(issue)/page/year:
   42,1211,1966

系列性分类

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