Ammonium, (4-(2-oxo-1-pyrrolidinyl)-2-butynyl)trimethyl-, iodide Oxotremorine M solid

CAS 3854-04-4 MFCD03854044

化学结构图

3854-04-4
SMILES: C[N+](C)(C)CCC#CN1CCCC1=O.[IH-]

化学属性

Mol. Weight322.22
Mol. FormulaC11H19N2O.I

别名和识别编码

Wiswesser Line NotationT5NVTJ A2UU2K1&1&1 &I
Chemical NameAmmonium, (4-(2-oxo-1-pyrrolidinyl)-2-butynyl)trimethyl-, iodide
Synonym (4-(2-Oxo-1-pyrrolidinyl)-2-butynyl)trimethylammonium iodide Trimethyl(4-(2-oxopyrrolidin-1-yl)but-2-ynyl)ammonium iodide
CAS Number3854-04-4
InChIKeyCHRKORSYUQVKAQ-UHFFFAOYSA-M
Chemical Name TranslationOxotremorine M solid
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相关文献及参考

  • [2]. Zwart R, et al. A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockadeby Oxotremorine-M. Eur J Pharmacol. 2016 Nov 15;791:221-228.
  • [3]. Tran JA, et al. Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse. J Pharmacol Exp Ther. 2006 Aug;318(2):649-56. Epub 2006 May 4.
  • [4]. Ichikawa J, et al. Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Brain Res. 2002 Dec 20;958(1):176-84.
  • [1]. Zwart R, et al. Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independentmechanisms. Biochem Biophys Res Commun. 2018 Jan 1;495(1):481-
  • [1]. Zwart R, et al. Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independentmechanisms. Biochem Biophys Res Commun. 2018 Jan 1;495(1):481-486.

安全信息

RTECSBR9970000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 26,56,1966

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. mAChR  (毒蕈碱型乙酰胆碱受体)

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