Oleandomycin 竹桃霉素

CAS 3922-90-5 MFCD00242812

化学结构图

3922-90-5
SMILES: CO[C@@H]1C[C@H](O[C@H](C)[C@H]1O)O[C@H]1[C@H](C)C(=O)O[C@@H](C)[C@@H](C)[C@@H](O)[C@H](C)C(=O)[C@@]2(CO2)C[C@@H](C)[C@@H](O[C@H]2O[C@@H](C)C[C@H]([C@@H]2O)N(C)C)[C@@H]1C |&1:2,4,6,8,11,12,17,19,21,23,27,31,33,35,37,40,41,46|

化学属性

Mol. FormulaC35H61NO12
Mol. Weight688

别名和识别编码

Chemical NameOleandomycin
CAS Number3922-90-5
Synonym PA 775 ######## Amimycin Oleandomycine Romicil Antibiotic PA-105
Chemical Name Translation竹桃霉素
Wiswesser Line NotationT-14-VO GVXTJ C1 D1 EQ F1 J1 L1 N1 H-& BT3OX CHJ& KO-BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO
MDL Number
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分类

  • Carbohydrates & Derivatives
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Antibiotic substance produced by Streptomyces antibioticus no. ATCC 11891. Antibacterial.

相关文献及参考

  • Sous, H., et al.: Arzneim.-Forsch., 8, 386 (1958),
  • Hahn, et al.: Antibiotics, 1, 378 (1967),

安全信息

RTECSRJ9220000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2343 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de
   Securite Sociale.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.7-    1946-
   Volume(issue)/page/year: 39,259,1978

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
   Tokyo, Univ. of Tokyo Press, 1967  Volume(issue)/page/year: -,475,1967

TYPE OF TEST            : LD50

系列性分类

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