Fluorometholone 氟米龙

CAS 426-13-1 MFCD00056461

化学结构图

426-13-1
SMILES: CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C

化学属性

Mol. FormulaC22H29FO4
Mol. Weight376.47
Density1.422
Refractive index55 ° (C=1, Pyridine)

别名和识别编码

Chemical NameFluorometholone
CAS Number426-13-1
Synonym fluoromethalone oxylone 11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione 氟米龙 Cortilet {Chemi 11-BETA,17-ALPHA-DIHYDROXY-9-FLUORO-6-METHYL-4-ANDROSTEN-3-ONE 11β,17α-dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6α, 11β)- cortilet Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-6α-methyl- Delmeson Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6α,11β)- 9a-Fluoro-11ß,17a-dihydroxy-6a-m Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6a, 11ß)- ######## 6a-Methyl-9a-fluoro-11ß,17a-dihydroxypregna-1,4-diene-3,20-dione {Ch 1,4-PREGNADIEN-9-ALPHA-FLUORO-6-ALPHA-METHYL-11-BETA, 17-DIOL-3,20-DIONE 9α-Fluoro-11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione {uni_hambu 11BETA,17ALPHA-DIHYDROXY-9-FLUORO-6-METHYL-1,4-PREGNADIENE-3 6α-Methyl-9α- Trilcin Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11ß)- 20-dione,9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl-pregna-4-diene-3 9a-fluoro-11b,17a-dihydroxy-6a-methyl-1,4-pregnadiene-3,20-dione pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-,(6-alpha,11-be Progesterone, 1-dehydro-9-fluoro-11ß, 17-dihydroxy-6a-methyl- {hazar 9a-Fluoro-11b,17a-dihydroxy-6a-methyl-1,4-pregnadiene-3,20-dione; 11b,17a-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-di U 8614 11b,17a-dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione 6a-Methyl-9a-fluoro-21-desoxypred
MDL NumberMFCD00056461
PubChem Substance ID9878
EC Number207-041-5
Reaxys-RN3172388
Merck Number4175
Beilstein Registry Number2384789
Chemical Name Translation氟米龙
LabNetwork Molecule IDLN01299210
InChIInChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
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分类

  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards,
  • {SNA} Cytokines, Growth Factors and Hormones, Hormones, Other Steroid Products, Steroid Hormones, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards E - F
  • {SNA} Analyti
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, F, Hormones, Other Steroid Products, Steroid Hormones

产品应用

  • Fluorometholone is a glucocorticoid; anti-inflammatory.

相关文献及参考

  • 1. Tabbara, K.F. and al-Kharashi S.A., Efficacy of nedocromil 2% versus fluorometholone 0.1%: a randomised, double masked trial comparing the effects on severe vernal keratoconjunctivitis Br. J. Ophthalmol. 83 , 180-184, (1999)
  • Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982),
  • Merck 14 ,4175
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: htt
  • Short: II/27C Title: Diamagnetic Susceptibility and Magnetic Anisotropy of Organic Compounds Author: Kumar, Mahendra; Gupta, Rajni Editor: Gupta, Radha Raman Source: Landolt-Börnstein, New Series Volume: II/27C Year: 2008 Keyword: diamagnetic susceptibility; magnetic anisotropy; organic compounds ISBN: 978-3-540-44734-4 (print) ISBN: 978-3-540-44736-8 (online) Internet Resource: doi:10.1007/978-3-540-44736-8 RefComment: VIII,

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340+P312
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P305+P351+P338
  • P302+P352+P312+P362+P364
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
Signal word
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302+H312+H332
Hazard Codes Xn
RTECSTU3834100
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,2349,1974

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 8,2349,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 443 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,981,1990

其他信息

  • TCI Shanghai:氟米龙 Fluorometholone,>;98.0%(LC)(426-13-1)
  • MOL 文件:426-13-1.mol
  • 氟米龙价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 F0414 氟米龙 Fluorometholone 1G 2700元
  • 氟米龙价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0414 氟米龙 Fluorometholone 1G 3430元
  • MSDS 信息:11b,17a-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione(426-13-1).msds
  • Sigma Aldrich:426-13-1(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Other Steroid Products - Steroid Hormones
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)

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