Codeine phosphate (anhydrous)
CAS 52-28-8 MFCD00052288
化学结构图
SMILES: COc1ccc2c3c1O[C@H]1[C@@H](OP(=O)(O)O)C=C[C@H]4[C@@H](C2)N(C)CC[C@]314
化学属性
| Mol. Weight | 397.40 |
|---|---|
| Mol. Formula | C18H21NO3.H3O4P |
别名和识别编码
| CAS Number | 52-28-8 |
|---|---|
| Chemical Name | Morphinan-6-alpha-ol,7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-,phosphate (1:1) |
| Synonym | Codicept Phosphate Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, Codeine phosphate Galcodine (-)-Codeine phosphate (-)-Codeine Phosphate (5?,6?)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methyl-morphinan-6-ol Phosphate Coducept Phosphate Tricodein Morphine 3-Methyl Ether Phosphate |
| InChIKey | WUXLCJZUUHIXFY-FFHNEAJVSA-N |
| Wiswesser Line Notation | T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JO1 P1&P-O4 |
| PubChem Substance ID | 5359227 |
| InChI | InChI=1S/C18H21NO3.H3O4P/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4)/t11-,12+,13-,17-,18-;/m0./s1 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive.
相关文献及参考
- Eddy, S., et al.: J. Pharmacol. Exp. Ther., 67, 127 (1939),
- Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 10, 93 (1981),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kil
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1916,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,538,1967
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Wa
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1207,1972
TYPE OF TEST : LD
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE : 97 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 123,705,1975
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 110 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : DGDFA5 Development, Growth & Differentiation. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.11- 1969- Volume(issue)/page/year: 22,61,1980
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