Sarcolysin
CAS 531-76-0 MFCD00531760
化学结构图
SMILES: NC(Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O
化学属性
| Mol. Formula | C13H18Cl2N2O2 |
|---|---|
| Mol. Weight | 305.23 |
别名和识别编码
| Chemical Name | Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, DL- |
|---|---|
| Chemicalbook ID | CB91179708 |
| Synonym | 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine 4-(Bis(2-chloroethyl)amino)phenylalanine Alkeran CB-3307 DL-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine DL-Phenylalanine mustard DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)- DL-Sarcolysin DL-Sarcolysine L-PAM Medphalan Melphalan Merfalan Merphalan Mustard, Phenylalanine NCI-CO4944 NSC-14210 O-Merphalan Phenylalanin-lost Phenylalanine Mustard Sarcoclorin Sarcolysine Sarkolysin dl-Phenylalanin-lost p-Di(2-chloroethyl)amino-DL-phenylalanine p-Di-(2-chloraethyl)-amino-DL-phenyl-alanin |
| Wiswesser Line Notation | QVYZ1R DN2G2G -DL |
| CAS Number | 531-76-0 |
| LabNetwork Molecule ID | LN00263781 |
| PubChem Substance ID | 4053 |
| InChI | InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19) |
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安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 98 mg/kg/26W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 40,1935,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain Tumorigenic - active as anti-cancer agent REFERENCE : AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year: 20,144,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,340,1958
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DKBSAS Doklady Biological Sciences (English Translation). Translation of DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.112- 1957- Volume(issue)/page/year: 171,801,1966
TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 200 mg/L REFERENCE : ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94, 1930-73. For publisher information, see AMICCW. Volume(issue)/page/year: 51,9,1965
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 10 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 23,5,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 5 mg/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : DKBSAS Doklady Biological Sciences (English Translation). Translation of DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.112- 1957- Volume(issue)/page/year: 171,801,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 8 mg/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : DKBSAS Doklady Biological Sciences (English Translation). Translation of DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.112- 1957- Volume(issue)/page/year: 171,801,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 8 mg/kg SEX/DURATION : female 4 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : DKBSAS Doklady Biological Sciences (English Translation). Translation of DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.112- 1957- Volume(issue)/page/year: 171,801,1966
TYPE OF TEST
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