Synephrine hydrochloride 辛弗林盐酸盐

CAS 5985-28-4 MFCD00050566

化学结构图

5985-28-4
SMILES: CNCC(O)c1ccc(O)cc1.Cl

化学属性

Mol. FormulaC₉H₁₄ClNO₂
Mol. Weight203.67
Melting Point>135°C
Boiling Point
Flash Point-

别名和识别编码

Chemical NameSynephrine hydrochloride
CAS Number5985-28-4
Alfabeta NameHYDROXYMETHYLAMINOETHYLPHENOLHYDROCHLORIDE 412(())-----
MDL Number-
Synonym (±)-Oxedrine hydrochloride (±)-p-Hydroxynorephedrine hydrochloride 1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride 1-(4-羟基苯基)-2-(甲基氨基)-乙醇盐酸盐 4-Hydroxy-?-[(methylamino)methyl]benzenemethanol Hydrochloride 4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride 4-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol hydrochloride Benzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-, hydrochloride N-METHYL OCTOPAMINE HCL Oxedrine Hydrochloride SYNEPHRINE HCL SYNEPHRINE HYDROCHLORIDE SYNEPHRINE HYDROCHLORIDE 98.0%MIN Sympathol hydrochloride Synephrine Hydrochloride Synephrine hydrochloride dl-p-Hydroxynorephedrine hydrochloride l-1-p-Hydroxyphenyl-2-methylamino-1-ethanol hydrochloride l-1-p-hydroxyphenyl-2-me
EC Number227-804-6
Chemical Name Translation辛弗林盐酸盐
Wiswesser Line NotationQR DYQ1M1 &GH
LabNetwork Molecule IDLN00177611
PubChem Substance ID42609626
InChIInChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
Canonical SMILES-
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分类

  • Amines
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • A ?-adrenergic receptor agonist, vasoconstrictor.

相关文献及参考

  • [2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8.
  • Louw, A., et al.: Biochem. Pharmacol., 53, 189 (1997),
  • [1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90.
  • [1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90.
  • [2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8.

安全信息

Warnings IRRITANT
RTECSDO7700000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 124,231,1927

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 124,231,1927

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 71,62,1941

GHS Symbol
UN Number 3077
Hazard Codes 9
Signal word Warning
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P312
  • P330 Rinse mouth. 漱口
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing GroupIII
Storage condition 4 4°C, Hygroscopic

其他信息

  • MOL 文件:5985-28-4.mol

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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