α-Mangostin α-倒捻子素

CAS 6147-11-1 MFCD00135200

化学结构图

6147-11-1
SMILES: COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C

化学属性

Mol. FormulaC24H26O6
Mol. Weight410.46
Density1.265
Melting Point180-182°C

别名和识别编码

Chemical Nameα-Mangostin
CAS Number6147-11-1
Synonym 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2- butenyl)-9H-xanthen-9-one 7-O-methyl-4-desprenylcostatin 7-O-methyl-gamma-mangostin alfa-mangostin alpha-Mangostin alpha-mangosten alpha-mangostin mangostin {} {LY} alpha-Mangostin {} {} {LY} alpha-Mangostin {} {} {} {LY} Mangostin {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Mangostin {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} alpha-Mangostin {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00135200
EC Number448-420-7
Chemical Name Translationα-倒捻子素
Reaxys-RN362302
PubChem Substance ID5281650
LabNetwork Molecule IDLN00197775
InChIInChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
Canonical SMILESO=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
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分类

  • Pharmaceuticals
  • {SNA} Nutrition Research, Phenols, Phytochemicals by Chemical Classification, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM)
  • Intermediates & Fine Chemicals,
  • {SNA} Phenols, Phytochemicals by Chemical Classification, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 细胞生物学, 营养研究

产品应用

  • 高纯度α-倒捻子素由于成份明确，可作为医药原料、保健品等。

相关文献及参考

  • [2]. Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48.
  • Chairungsrilerd, N., et al.: Planta Med., 62, 471
  • Merck: 14,5742
  • [1]. Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31.
  • [1]. Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5625-31.
  • [2]. Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48.

安全信息

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes 6.1 T
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P301+P312+P330
  • P301+P316
  • P301+P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
WGK Germany1
Signal word Danger
RTECSZD6122420
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} +4°C {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} +4°C {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Packing GroupIII
UN Number 2811

其他信息

  • 用途一:高纯度α-倒捻子素由于成份明确，可作为医药原料、保健品等。
  • MOL 文件:6147-11-1.mol

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM) - Nutrition Research
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)

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