5-(4,5-Dimethoxy-2-Methylbenzyl)Pyrimidine-2,4-Diamine 5-(4,5-二甲氧基-2-甲基苄基)嘧啶-2,4-二胺

CAS 6981-18-6 MFCD00057747

化学结构图

6981-18-6
SMILES: COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC

化学属性

Mol. FormulaC14H18N4O2
Mol. Weight274
Melting Point231-235

别名和识别编码

Chemical Name5-(4,5-Dimethoxy-2-Methylbenzyl)Pyrimidine-2,4-Diamine
CAS Number6981-18-6
Synonym 2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine 2,4-diamino-5-(6-methylveratryl)pyrimidine 5-(4,5-二甲氧基-2-甲基苄基)-2,4-二氨嘧啶 ormetoprim
EC Number230-246-6
MDL NumberMFCD00057747
Chemical Name Translation5-(4,5-二甲氧基-2-甲基苄基)嘧啶-2,4-二胺
Reaxys-RN760209
Beilstein Registry Number760209
PubChem Substance ID23418
LabNetwork Molecule IDLN01306443
InChIInChI=1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18)
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分类

  • Heterocycles
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial.

相关文献及参考

  • Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978),
  • Roth, B., et al.: J. Med. Chem., 23, 379 (1980),
  • Brogden, R.N., et al.: Drugs, 23, 405 (1982),

安全信息

Storage condition 0-6°C
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P337+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • Sigma Aldrich:6981-18-6(sigmaaldrich)
  • MOL 文件:6981-18-6.mol

系列性分类

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