Trifluorothymidine 曲氟胸苷

CAS 70-00-8 MFCD00006534

化学结构图

70-00-8
SMILES: O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F

化学属性

Mol. FormulaC10H11F3N2O5
Mol. Weight296.20
Melting Point190-193°C
SolubilityDMSO 59 mg/mL Water 59 mg/mL Ethanol 59 mg/mL
Refractive index50 ° (C=1, H2O)

别名和识别编码

Chemical NameTrifluorothymidine
CAS Number70-00-8
Alfabeta NameTRIFLUOROTHYMIDINE 5-
MDL NumberMFCD00006534
Synonym Trifluridine {LY} Trifluridine {} {LY} Trifluridine {} {} {LY} Trifluridine {} {} {} {LY} Trifluridine {} {} {} {} {LY} Trifluridine {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Trifluridine {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID6256
EC Number200-722-8
Chemical Name Translation曲氟胸苷
Merck Number9687
Reaxys-RN568095
Beilstein Registry Number568095
Wiswesser Line NotationT6NVMVJ EXFFF A- ET5OTJ B1Q CQ
LabNetwork Molecule IDLN00171457
InChIInChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
Canonical SMILESO[C@H]1C[C@H](N2C(NC(C(C(F)(F)F)=C2)=O)=O)O[C@@H]1CO
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分类

  • Bases & Related Reagents
  • {SNA} Nucleoside Analogs, 核苷,核苷酸和寡核苷酸, 生化试剂
  • Nucleotides
  • {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
RTECSXP2087500
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xn,Xi Xi
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2946 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,260,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3381 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur
   D. Little, Inc. (15 Acorn Park, Cambridge, MA 02140)
   Volume(issue)/page/year: -,260,1967

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GVRAAS Government Reports Announcements. (U.S.)  (Washington, D.C.) V.71(6)
   -75(6), 1971-75. Merged with Government Reports Index (US) to form
   Government Reports Announcement Index (U.S.)  Volume(issue)/page/year:
   74(9),60,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1931 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 150 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 312,85,1994

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 16 mg/L
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   86,180,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 ug/L
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,520,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 500 ug/L
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,520,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 6,1207,1985

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 4 mg/L
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   86,180,1986

{hazard

其他信息

  • Sigma Aldrich:70-00-8(sigmaaldrich)
  • 用途一:广谱抗病毒药物,对单纯疱疹病毒、腺病毒、带状疱疹病毒等有抑制作用,对HSV-I ,HSV-II,CMV,水痘病毒及某些腺病毒具抑制作用。
  • TCI Shanghai:曲氟胸苷 Trifluorothymidine,>;97.0%(T)(70-00-8)
  • MSDS 信息:2'-Deoxy-5-(trifluoromethyl)uridine(70-00-8).msds
  • 曲氟胸苷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T2511 曲氟胸苷 Trifluorothymidine 1G 8450元 2014/06/02 T2511 曲氟胸苷 Trifluorothymidine 100MG 1210元
  • MOL 文件:70-00-8.mol
  • Hazard Note:Keep Cold
  • 曲氟胸苷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T2511 曲氟胸苷 Trifluorothymidine 1G 6670元 2011/04/16 T2511 曲氟胸苷 Trifluorothymidine 100MG 948元

系列性分类


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