2-Amino-5-chlorobenzophenone 2-氨基-5-氯二苯甲酮

CAS 719-59-5 MFCD00007839

化学结构图

719-59-5
SMILES: Nc1ccc(Cl)cc1C(=O)c1ccccc1

化学属性

Mol. FormulaC13H10ClNO
Mol. Weight231.68
Melting Point96-98°C
Density2.63
Flash Point211°(412°F)
TSCAYes
Boiling Point207 °C at 760 mmHg
Appearance 黄色或亮黄色针状结晶

别名和识别编码

Chemical Name(2-Amino-5-chlorophenyl)(phenyl)methanone
CAS Number719-59-5
Synonym 2-Amino-5-chlorobenzophenone {LY} 2-Amino-5-chlorobenzophenone 2-amino-5-chlorobenzophenone {} {LY} 2-Amino-5-chlorobenzophenone {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {PubChem} 2-ACB {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-5-chlorobenzophenone
Beilstein Registry Number475640
PubChem Substance ID12870
EC Number211-949-7
MDL NumberMFCD00007839
Reaxys-RN475640
Chemical Name Translation2-氨基-5-氯二苯甲酮
LabNetwork Molecule IDLN00194124
InChIInChI=1S/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2
Canonical SMILESO=C(C1=CC=CC=C1)C2=CC(Cl)=CC=C2N
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分类

  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B
  • Building Blocks, C13 to C14, Carbonyl Compounds, Chemical Synthesis, Ketones, Organic Building Blocks
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ketone; 1fragment
  • {SA} Building Blocks, C13 to C14, Carbonyl Compounds, Chemical Synthesis, Ketones,

产品应用

  • 医药中间体。生产利眠安、安定等药物。

相关文献及参考

  • Hara, T., et al.: J. Med. Chem., 21, 263 (1978),
  • Short: EINECS
  • Beilstein:14(3)214
  • Short: III/20b

安全信息

Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
WGK Germany3
GHS Symbol
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xn Xi Xi,Xn
RTECSPC4933500
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 681 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJSIDW Indian Journal of Pharmaceutical Sciences.  (Kalina, Santa Cruz
   (East), Bombay 400 029, India)  V.40(2)-    1978-  Volume(issue)/page/year:
   44,1,1982

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • 2-氨基-5-氯二苯甲酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0079 2-氨基-5-氯二苯甲酮 2-Amino-5-chlorobenzophenone 25G 195元 2014/06/02 A0079 2-氨基-5-氯二苯甲酮 2-Amino-5-chlorobenzophenone 500G 1200元 2010/06/21 103345000 2-氨基-5-氯二苯甲酮 2-Amino-5-chlorobenzophenone 98% 500 GR 1202元
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氯化物烟雾
  • 用途一:用作医药中间体，主要用于制备利眠宁、安定、舒乐安定等镇静药物
  • 用途二:医药中间体。生产利眠安、安定等药物。
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 毒性分级:中毒
  • Alfa Aesar:2-氨基-5-氯苯并苯酮,98+% 2-Amino-5-chlorobenzophenone, 98+%(719-59-5)
  • 图谱信息:2-氨基-5-氯二苯甲酮(719-59-5)红外图谱(IR1) 2-氨基-5-氯二苯甲酮(719-59-5)红外图谱(IR2) 2-氨基-5-氯二苯甲酮(719-59-5)核磁图( 1 HNMR) 2-氨基-5-氯二苯甲酮(719-59-5)核磁图( 13 CNMR) 2-氨基-5-氯二苯甲酮(719-59-5)质谱(MS)
  • 下游产品:2-氨基-5-氯二苯酮肟 --> 地莫西泮 --> 地西泮 --> 氯氮卓
  • 不溶于水。
  • 海关编码:29223900
  • Acros Organics:2-氨基-5-氯二苯甲酮 2-Amino-5-chlorobenzophenone, 98%(719-59-5)
  • 储运特性:库房通风低温干燥
  • 急性毒性:腹腔-小鼠LD50:681 毫克/公斤
  • 上游原料:氯化锌 --> Α-球蛋白 --> 苯甲酰氯 --> 4-硝基氯苯 --> 4-氯苯胺 --> 搪玻璃反应锅 --> 糠酸 --> 氰苄 --> 异恶唑
  • MOL 文件:719-59-5.mol
  • 方法一:（1）由对氯苯胺与苯甲酰氯反应制得。先将对氯苯加入搪玻璃反应锅中，在70℃以下，投入无水氯化锌，在搅拌下滴加苯甲酰氯，然后升温，在195-205℃保温2h后，用90-95℃的热水洗涤五次（水层及洗液回收苯甲酸与氯化锌）在100℃左右，将硫酸徐徐加入，在142℃保温40min。趁热将料液注入0-5℃水中，析出固体。在搅拌下，用液碱调节pH不高于1，在20-25℃时过滤。滤液回收对氯苯胺。滤饼混悬于水中，中和至pH=6，滤干，用水洗至中性，烘干得粗品。然后加6-7倍乙醇，6%活性炭，回流30min，过滤结晶，烘干而得精品。（2）对硝基氯苯与氰苄环合得异噁唑，再开环，还原而得。
  • 类别:有毒物品
  • TCI Shanghai:2-氨基-5-氯二苯甲酮 2-Amino-5-chlorobenzophenone,>;98.0%(T)(719-59-5)
  • Sigma Aldrich:719-59-5(sigmaaldrich)
  • MSDS 信息:5-Chloro-2-aminobenzophenone(719-59-5).msds

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  6. C13 to C14 - Ketones
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aromatic Ketones
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones 酮
  6. C11 to C12

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