3-Demethylcolchicine 3-去甲秋水仙碱
CAS 7336-33-6 MFCD N/A
化学结构图
SMILES: COc1c(O)cc2c(c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
化学属性
| Mol. Weight | 385.41 |
|---|---|
| Mol. Formula | C₂₁H₂₃NO₆ |
| Melting Point | 163-166°C (dec.) |
| Boiling Point | |
| Flash Point | - |
别名和识别编码
| CAS Number | 7336-33-6 |
|---|---|
| Chemical Name | 3-Demethylcolchicine |
| Synonym | 3-Demethyl Colchicine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
| Chemical Name Translation | 3-去甲秋水仙碱 |
| Wiswesser Line Notation | L B677 MV&T&J CO1 DO1 EQ JMV1 NO1 |
| Canonical SMILES | - |
| MDL Number | - |
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分类
- Chiral Reagents
- Inhibitors
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A metabolite of Colchicine (C640000). Has shown anti-tumor activity.
相关文献及参考
- [2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.
- Das, D., et al.: Biochim. Biophys. Acta., 1502, 351 (2000),
- De Vincenzo, R., et al.: Oncol. Res., 11, 145(1999),
- Martinez, M., et al.: J. Appl. Toxicol., 15, 49 (1995),
- [1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117.
- [1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117.
- [2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 570 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
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