PDGFR

下级目录

TAK-593

SIM010603

SKLB610

Henatinib

PD089828

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

AAL-993

Crenolanib

XL999

N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide

R1530

AZD-2932

LY2457546

3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-YL)methylene]-2-indolinone

Axitinib

Masitinib

木利替尼

1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea

5-[4-[(2,3-Dimethyl-2H-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino]-2-methyl-benzenesulfonamide

PD-166866

瑞格非尼

目录项下的产品

1005780-62-0 / MFCD105780620
TAK-593 is a n oral formulation containing a small-molecule receptor tyrosine kinase inhibitor of both vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with potential antineoplastic activity. TAK-593 selectively binds to and inhibits VEGFR and PDGFR, which may result in the inhibition of angiogenesis and tumor cell proliferation.

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1032265-67-0 / MFCD132265670
SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.

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1125780-41-7 / MFCD20261423
N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide
N-甲基-4-(4-(3-(三氟甲基)苯甲酰氨基)苯氧基)吡啶-2-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1239269-51-2 / MFCD339269512
Henatinib maleate is t he maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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试剂

179343-17-0 / MFCD79343170
PD089828

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试剂

252916-29-3 / MFCD52916293
3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

269390-77-4 / MFCD69390774
AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

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670220-88-9 / MFCD70220889
1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine
[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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705946-27-6 / MFCD05946276
(Z)-5-((1-Ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one
(Z)-5-((1-乙基哌啶-4-基)氨基)-3-((3-氟苯基)(5-甲基-1H-咪唑-2-基)亚甲基)吲哚啉-2-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

850879-09-3 / MFCD50879093
N-(Benzo[D][1,3]Dioxol-5-Ylmethyl)-4-(Benzofuro[3,2-d]Pyrimidin-4-Yl)Piperazine-1-Carbothioamide
N-(苯并[d][1,3]二氧杂环戊烷-5-基甲基)-4-(苯并呋喃并[3,2-d]嘧啶-4-基)哌嗪-1-甲硫酰胺

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882531-87-5 / MFCD82531875
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) betaÂ‚ FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.

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883986-34-3 / MFCD83986343
2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
2-(4-((6,7-二甲氧基喹唑啉-4-基)氧基)苯基)-N-(1-异丙基-1H-吡唑-4-基)乙酰胺

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908265-94-1 / MFCD008265941
LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 syngeneic rat mammary tumor models. Additionally, LY2457546 caused complete regression of well-established tumors in an acute myelogenous leukemia (AML) FLT3-ITD mutant xenograft tumor model. The unique spectrum of target activity, potent in vivo anti-tumor efficacy in a variety of rodent and human solid tumor models, exquisite potency against a clinically relevant model of AML, and non-clinical safety profile justify the advancement of LY2457546 into clinical testing. (source: Invest New Drugs. 2012

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215543-92-3 / MFCD08235144
SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively).
SU5402

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319460-85-0 / MFCD09837898
Axitinib
阿西替尼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

790299-79-5 / MFCD09954132
Masitinib, also known as AB1010, is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs). Masitinib was approved for veterinary use.
马塞替尼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

366017-09-6 / MFCD09954135
Mubritinib
木利替尼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

228559-41-9 / MFCD09971092
1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea
1-(2,4-二氟苯基)-3-(4-((6,7-二甲氧基喹啉-4-基)氧基)-2-氟苯基)脲

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

444731-52-6 / MFCD11616589
Pazopanib
帕唑帕尼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

192705-79-6 / MFCD12922514
PD166866
1-(2-氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-d]嘧啶-7-基)-3-(叔丁基)脲

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

755037-03-7 / MFCD16038047
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
4-[4-[[[4-氯-3-(三氟甲基)苯基]氨基甲酰]氨基]-3-氟苯氧基]-N-甲基吡啶-2-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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中华人民共和国
√

PDGFR

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PDGFR

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