VEGFR

下级目录

Henatinib

FIIN-1

AAL-993

AEE 788

Foretinib

CEP-11981

AZD-2932

Golvatinib

3-[(4-BROMO-2,6-DIFLUOROPHENYL)METHOXY]-5-[[[[4-(1-PYRROLIDINYL)BUTYL]AMINO]CARBONYL]AMINO]-4-ISOTHIAZOLECARBOXAMIDE

Axitinib

1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-IODO-4-[[3-[(2-THIENYLCARBONYL)AMINO]PROPYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-

Bms-690514

目录项下的产品

1239269-51-2 / MFCD339269512
Henatinib maleate is t he maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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1256152-35-8 / MFCD356152358
FIIN-1

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269390-77-4 / MFCD69390774
AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

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497839-62-0 / MFCD97839620
{6-[4-(4-Ethylpiperazin-1-Ylmethyl)-Phenyl]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}-((R)-1-Phenylethyl)Amine
{6-[4-(4-乙基哌嗪-1-基甲基)-苯基]-7H吡咯并[2,3-d]嘧啶-4-基}-((R)-1-苯基乙基)胺

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849217-64-7 / MFCD49217647
N-(3-Fluoro-4-((6-Methoxy-7-(3-Morpholinopropoxy)Quinolin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide
N-(3-氟-4-((-甲氧基-7-(3-吗啉代丙氧基)喹啉-4-基)氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二甲酰胺

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856691-93-5 / MFCD56691935
CEP-11981

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883986-34-3 / MFCD83986343
AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR. AZD-2932 has a balanced ~ 1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes, respectively. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. The pharmacokinetic behavior and the preclinical antitumor activity in nude mice bearing C6 rat glial tumors indicate that 31 has the potential to become an antiangiogenic agent in the clinic.

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928037-13-2 / MFCD028037132
N-(2-Fluoro-4-((2-(4-(4-Methylpiperazin-1-Yl)Piperidine-1-Carboxamido)Pyridin-4-Yl)Oxy)Phenyl)-N-(4-Fluorophenyl)Cyclopropane-1,1-Dicarboxamide
N-[2-氟-4-[[2-[[[4-(4-甲基哌嗪-1-基)哌啶-1-基]羰基]氨基]吡啶-4-基]氧基]苯基]-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺

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252003-65-9 / MFCD07772279
CP-547632, also known as PAN-90806, is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor , and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation for the treatment of human malignancies.

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319460-85-0 / MFCD09837898
Axitinib
阿西替尼

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中华人民共和国
√

702675-74-9 / MFCD12546134
N-[3-[[5-Iodo-4-[[3-[(2-Thienylcarbonyl)Amino]Propyl]Amino]-2-Pyrimidinyl]Amino]Phenyl]-1-Pyrrolidinecarboxamide
N-[3-[[5-碘-4-[[3-[(2-噻吩基羰基)氨基]丙基]氨基]-2-嘧啶基]氨基]苯基]-1-吡咯烷甲酰胺

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试剂

中华人民共和国

859853-30-8 / MFCD18633295
Bms-690514
BMS-690514

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VEGFR

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