PERK

下级目录

7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine

CID 53469059

GDC-0879

G-573

PD-184352

目录项下的产品

1337531-36-8

1337531-36-8 / MFCD437531368
GSK2606414 is an orally available, potent, and selective PERK inhibitor. GSK2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors.
1-(5-(4-氨基-7-甲基-7H-吡咯并[2,3-d]嘧啶-5-基)二氢吲哚-1-基)-2-(3-(三氟甲基)苯基)乙酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1337532-29-2

1337532-29-2 / MFCD437532292
CID 53469059
1-(5-(4-氨基-7-甲基-7H-吡咯并[2,3-d]嘧啶-5-基)-4-氟吲哚啉-1-基)-2-(6-甲基吡啶-2-基)乙酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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905281-76-7

905281-76-7 / MFCD005281767
(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime
2,3-二氢-5-[1-(2-羟基乙基)-3-(4-吡啶基)-1H-吡唑-4-基]-1H-茚-1-酮肟

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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22868-35-5

22868-35-5 / MFCD01438282
G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406 ÂµM. The IC(50) values for tumour growth inhibition in HCT116 and H2122 were estimated to be 3.43 and 2.56 ÂµM, respectively. ED(50) estimates in HCT116 and H2122 mouse xenograft models were estimated to be ~4.6 and 1.9 mg/kg/day, respectively.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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212631-79-3

212631-79-3 / MFCD02683961
CI-1040
2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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中华人民共和国
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