Aurora Kinase

下级目录

NameC

Alisertib

Chiauranib

MK 0457

Barasertib

Danusertib

Cenisertib

AKI-001

N-[2-[(1R,8S)-4-[[4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl]acetamide

CCT129202

AMG900

Reversine

AZD1152-HQPA

目录项下的产品

1000669-72-6 / MFCD100669726
KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. (source: Clin Cancer Res. 2011 May 15;17(10):3219-32. Epub 2011 Apr 7.).
NameC

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1028486-01-2 / MFCD128486012
4-((9-Chloro-7-(2-Fluoro-6-Methoxyphenyl)-5H-Benzo[C]Pyrimido[4,5-E]Azepin-2-Yl)Amino)-2-Methoxybenzoic Acid
4-((9-氯-7-(2-氟-6-甲氧基苯基)-5H-苯并[c]嘧啶并[5,4-d]氮杂卓-2-基)氨基)-2-甲氧基苯甲酸

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

1256349-48-0 / MFCD356349480
N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide
N-(2-氨基苯基)-6-[(7-甲氧基-4-喹啉基)氧基]-1-萘甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

639089-54-6 / MFCD39089546
Tozasertib
陶扎色替

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

722543-31-9 / MFCD22543319
2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate
5-[[7-[3-[乙基[2-(磷酰氧基)乙基]氨基]丙氧基]-4-喹唑啉基]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

827318-97-8 / MFCD27318978
(R)-N-(5-(2-Methoxy-2-Phenylacetyl)-1,4,5,6-Tetrahydropyrrolo[3,4-c]Pyrazol-3-Yl)-4-(4-Methylpiperazin-1-Yl)Benzamide
(R)-N-(5-(2-甲氧基-2-苯乙酰基)-1,4,5,6-四氢吡咯并[3,4-c]吡唑-3-基)-4-(4-甲基哌嗪-1-基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

871357-89-0 / MFCD71357890
Cenisertib

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

925218-37-7 / MFCD025218377
AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

942487-16-3 / MFCD042487163
N-[2-[(1R,8S)-4-[[4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl]acetamide
PF-03814735

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

942947-93-5 / MFCD042947935
CCT129202

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

945595-80-2 / MFCD045595802
N-(4-((3-(2-Aminopyrimidin-4-Yl)Pyridin-2-Yl)Oxy)Phenyl)-4-(4-Methylthiophen-2-Yl)Phthalazin-1-Amine
N-(4-((3-(2-氨基嘧啶-4-基)吡啶-2-基氧基)苯基)-4-(4-甲基噻吩-2-基)酞嗪-1-胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

656820-32-5 / MFCD07784513
Reversine
N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

722544-51-6 / MFCD10687152
3-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazoline]Amino]-N-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide
5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

Aurora Kinase

下级目录

目录项下的产品

Products Indices

Mailings

Contact

链接

搜索结果

Aurora Kinase

下级目录

目录项下的产品

Products Indices

Mailings

Contact

链接