Aurora Kinase

下级目录

NameC

Alisertib

Chiauranib

MK 0457

Barasertib

Danusertib

Cenisertib

AKI-001

N-[2-[(1R,8S)-4-[[4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl]acetamide

CCT129202

AMG900

Reversine

AZD1152-HQPA

目录项下的产品

1000669-72-6 / MFCD100669726
KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. (source: Clin Cancer Res. 2011 May 15;17(10):3219-32. Epub 2011 Apr 7.).
NameC

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1028486-01-2 / MFCD128486012
4-((9-Chloro-7-(2-Fluoro-6-Methoxyphenyl)-5H-Benzo[C]Pyrimido[4,5-E]Azepin-2-Yl)Amino)-2-Methoxybenzoic Acid
4-((9-氯-7-(2-氟-6-甲氧基苯基)-5H-苯并[c]嘧啶并[5,4-d]氮杂卓-2-基)氨基)-2-甲氧基苯甲酸

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

1256349-48-0 / MFCD356349480
N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide
N-(2-氨基苯基)-6-[(7-甲氧基-4-喹啉基)氧基]-1-萘甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

639089-54-6 / MFCD39089546
Tozasertib
陶扎色替

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

722543-31-9 / MFCD22543319
Barasertib is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152–hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. IMPORTANT NOTE: AZD-1152HQPA IS NOT AZD-1152 or Barasertib. Many vendors is selling Barasertib with wrong structure

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

827318-97-8 / MFCD27318978
(R)-N-(5-(2-Methoxy-2-Phenylacetyl)-1,4,5,6-Tetrahydropyrrolo[3,4-c]Pyrazol-3-Yl)-4-(4-Methylpiperazin-1-Yl)Benzamide
(R)-N-(5-(2-甲氧基-2-苯乙酰基)-1,4,5,6-四氢吡咯并[3,4-c]吡唑-3-基)-4-(4-甲基哌嗪-1-基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

871357-89-0 / MFCD71357890
Cenisertib

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

925218-37-7 / MFCD025218377
AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near stasis (92% TGI) in an HCT116 mouse xenograft model.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

942487-16-3 / MFCD042487163
N-[2-[(1R,8S)-4-[[4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl]acetamide
PF-03814735

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

942947-93-5 / MFCD042947935
CCT129202

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

945595-80-2 / MFCD045595802
N-(4-((3-(2-Aminopyrimidin-4-Yl)Pyridin-2-Yl)Oxy)Phenyl)-4-(4-Methylthiophen-2-Yl)Phthalazin-1-Amine
N-(4-((3-(2-氨基嘧啶-4-基)吡啶-2-基氧基)苯基)-4-(4-甲基噻吩-2-基)酞嗪-1-胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

656820-32-5 / MFCD07784513
Reversine
逆转素

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

722544-51-6 / MFCD10687152
3-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazoline]Amino]-N-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide
5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

Aurora Kinase

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Aurora Kinase

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