Wee1

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Adavosertib

6-(2,6-DICHLOROPHENYL)-2-(4-(2-(DIETHYLAMINO)ETHOXY)PHENYLAMINO)-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE

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955365-80-7

955365-80-7 / MFCD055365807
2-Allyl-1-(6-(2-Hydroxypropan-2-Yl)Pyridin-2-Yl)-6-((4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-1H-Pyrazolo[3,4-D]Pyrimidin-3(2H)-One
2-烯丙基-1-(6-(2-羟基丙-2-基)吡啶-2-基)-6-(4-(4-甲基哌嗪-1-基)苯基氨基)-1H-吡唑并[3,4-D]嘧啶-3(2H)-酮

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中华人民共和国

185039-89-8

185039-89-8 / MFCD00950060
PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line.
PD0166285游离态

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