DNA-PK

下级目录

LY-3023414

2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

NU-7107

NU 7441

KU-0058684

SU-11752

NU-7199

NU-7031

NU-7200

L-Serine,N2-[1,4-dioxo-4-[[4-(4-oxo-8-phenyl-4H-1-benzopyran-2-yl)MorpholiniuM-4-yl]Methoxy]butyl]-L-arginylglycyl-L-a-aspartyl-,innersalt

OK-1035

NU7026

1-(2-HYDROXY-4-MORPHOLIN-4-YL-PHENYL)ETHANONE

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

目录项下的产品

1386874-06-1 / MFCD486874061
Samotolisib, also known as LY3023414, is a small molecule that has been shown in vitro to be a selective ATP-competitive inhibitor of PI3Kα and mTOR, DNA-PK, and other class I PI3K family members. In vitro, LY3023414 has demonstrated inhibitory activity against PI3K and mTOR in tumor cells, as well as antiproliferative activity and cell cycle effects. In addition, in vitro, LY3023414 inhibits the ability of PI3K and mTOR to phosphorylate substrates in the PI3K/mTOR pathway. LY3023414 is being investigated in a phase I clinical trial.
LY3023414游离态

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371242-69-2 / MFCD71242692
2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

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503465-21-2 / MFCD03465212
NU-7107 is a potent DNA-PK inhibitor with potential anticancer activity.

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503468-95-9 / MFCD03468959
8-(4-Dibenzothiophenyl)-2-(4-Morpholinyl)-4H-1-Benzopyran-4-One
8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮

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623578-11-0 / MFCD23578110
KU-0058684 is a potent PARP and DNA-PK inhibitors.

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688036-19-3 / MFCD88036193
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.

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69541-04-4 / MFCD69541044
NU-7199 is a potent DNA-PK inhibitor with potential anticancer activity.

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79105-88-7 / MFCD79105887
NU-7031 is a potent DNA-PK inhibitor with potential anticancer activity.

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842122-14-9 / MFCD42122149
NU-7200 is a potent DNA-PK inhibitor with potential anticancer activity.

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936487-67-1 / MFCD036487671
L-Serine,N2-[1,4-dioxo-4-[[4-(4-oxo-8-phenyl-4H-1-benzopyran-2-yl)MorpholiniuM-4-yl]Methoxy]butyl]-L-arginylglycyl-L-a-aspartyl-,innersalt
N2-[1,4-二氧代-4-[[4-(4-氧代-8-苯基-4H-1-苯并吡喃-2-基)吗啉-4-基]甲氧基]丁基]-L-精氨酰甘氨酰-L-ALPHA-天冬氨酰-L-丝氨酸内盐

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试剂

98293-88-0 / MFCD98293880
OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.

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154447-35-5 / MFCD06798345
2-(Morpholin-4-Yl)-Benzo[H]Chrome-4-One
2-(吗啉-4-基)-苯并[h]铬-4-酮

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404009-40-1 / MFCD07370140
1-(2-Hydroxy-4-Morpholinophenyl)Ethan-1-One
1-(2-羟基-4-吗啉苯基)乙酮

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试剂

1092351-67-1 / MFCD12196869
2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
2-(4-氨基-1-异丙基-1H-吡唑并[3,4-d]嘧啶-3-基)-1H-吲哚-5-醇

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中华人民共和国
北京市
√

DNA-PK

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DNA-PK

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