PARP

下级目录

E7449

AZD2461

DAT-230

Etalocib

Mahanine

Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one,2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-

CEP-6800

KU-0058684

JW55

L-2286

GPI-15427

E7016

CEP-9722

A-966492

CHLORIN E6

4-Iodo-3-nitrobenzamide

ABT 737

目录项下的产品

1140964-99-3 / MFCD240964993
8-(Isoindolin-2-ylmethyl)-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one
8-(异吲哚啉-2-基甲基)-1H-哒嗪并[3,4,5-de]喹唑啉-3(2H)-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1174043-16-3 / MFCD274043163
AZD2461
4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1504583-00-9 / MFCD604583009
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

161172-51-6 / MFCD61172516
2-(3-(3-((5-Ethyl-4'-Fluoro-2-Hydroxy-[1,1'-Biphenyl]-4-Yl)Oxy)Propoxy)-2-Propylphenoxy)Benzoic Acid
2-(3-(3-((5-乙基-4'-氟-2-羟基-[1,1'-联苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

28360-49-8 / MFCD28360498
Mahanine

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

328543-09-5 / MFCD28543095
AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells.
AG14361

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

609848-02-4 / MFCD09848024
CEP-6800 is a potent PARP inhibitor with potential anticancer activity. CEP-6800 could be used as a chemopotentiating agent with a variety of clinically effective chemotherapeutic agents.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

623578-11-0 / MFCD23578110
KU-0058684 is a potent PARP and DNA-PK inhibitors.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

664993-53-7 / MFCD64993537
JW 55
N-[4-[[[[四氢-4-(4-甲氧基苯基)-2H-吡喃-4-基]甲基]氨基]羰基]苯基]-2-呋喃甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

684276-17-3 / MFCD84276173
L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

805242-85-7 / MFCD05242857
GPI-15427

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

902128-92-1 / MFCD002128921
10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one
10-((4-羟基哌啶-1-基)甲基)苯并吡喃并[4,3,2-de]酞嗪-3(2H)-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

916574-83-9 / MFCD016574839
CEP-9722

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

934162-61-5 / MFCD034162615
A-966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP-1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

19660-77-6 / MFCD07364062
Chlorin E6
二氢卟吩E6

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

160003-66-7 / MFCD11110639
4-Iodo-3-Nitrobenzamide
3-硝基-4-碘苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

852808-04-9 / MFCD12756212
(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phenylthio)Butan-2-Yl)Amino)-3-Nitrophenyl)Sulfonyl)Benzamide
(R)-4-(4-((4'-氯-[1,1'-联苯]-2-基)甲基)哌嗪-1-基)-N-((4-((4-(二甲氨基)-1-(苯硫基)丁基-2-基)氨基)-3-硝基苯基)磺酰)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

PARP

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PARP

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