ERK

下级目录

Debio-0932 (CUDC305)

CCT196969

CCT241161

GDC-0623

GSK-2256098

(LGX818) Encorafenib

Kobe0065

Kobe-2602

AZD-8330

Chrysophanol

TYRPHOSTIN AG 490

AM251

PD-184352

GW5074

Diazepinomicin

N/A, 一种ATP-竞争性的选择性的ERK抑制剂

目录项下的产品

1061318-81-7 / MFCD161318817
Debio-0932 (CUDC305)

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1163719-56-9 / MFCD263719569
CCT196969

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1163719-91-2 / MFCD263719912
CCT241161 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT241161 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEKÂ–ERK, in vitro and in vivo. CCT241161 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1168091-68-6 / MFCD268091686
5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide
5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1224887-10-8 / MFCD324887108
2-((5-Chloro-2-((1-Isopropyl-3-Methyl-1H-Pyrazol-5-Yl)Amino)Pyridin-4-Yl)Amino)-N-Methoxybenzamide
2-((5-氯-2-((1-异丙基-3-甲基-1H-吡唑-5-基)氨基)吡啶-4-基)氨基)-N-甲氧基苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1269440-17-6 / MFCD369440176
(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
(S)-[1-[[4-[3-[5-氯-2-氟-3-(甲基磺酰胺基)苯基]-1-异丙基-1H-吡唑-4-基]嘧啶-2-基]氨基]丙-2-基]氨基甲酸甲酯

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

436133-68-5 / MFCD36133685
Kobe0065
N-(3-氯-4-甲基苯基)-2-[2,6-二硝基-4-(三氟甲基)苯基]肼基硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

454453-49-7 / MFCD54453497
2-(2,6-Dinitro-4-(trifluoromethyl)phenyl)-N-(4-fluorophenyl)hydrazine-1-carbothioamide
2-[2,6-二硝基-4-(三氟甲基)苯基]-N-(4-氟苯基)肼基硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

869357-68-6 / MFCD69357686
AZD8330, also known as ARRY704 and ARRY424704, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

481-74-3 / MFCD00001208
Chrysophanic acid
大黄酚

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
上海市
√

133550-30-8 / MFCD00209833
(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide
(E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

183232-66-8 / MFCD01861181
1-(24-Dichlorophenyl)-5-(4-Iodophenyl)-4-Methyl-N-(Piperidin-1-Yl)-1H-Pyrazole-3-Carboxamide
1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

212631-79-3 / MFCD02683961
CI-1040
2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

220904-83-6 / MFCD03453076
3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

733035-26-2 / MFCD09955031
Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the phosphorylation and activation of proteins downstream of the Ras signal transduction pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK-2). This agent also selectively binds to the peripheral benzodiazepine receptor (PBR), a receptor highly expressed in certain tumor cell types cells, inducing cell cycle arrest and apoptosis in PBR-expressing cells. Diazepinomicin can cross the blood-brain barrier (BBB).

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

865362-74-9 / MFCD14585805
FR180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.FR180204 showed activity to inhibit ERKs (IC50 values are 0.14 and 0.31 μ M for ERK2 and ERK1 respectively).
5-(2-苯基吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]哒嗪-3-胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

ERK

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ERK

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