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Medical Research Areas
L01-Proteases (36) ||[cs]: . Proteases
LCZ696 沙库巴曲缬沙坦钠
ALK
ALK
下级目录
CEP-28122
ASP-3026
Entrectinib
GSK1838705A
AZD-3463
Ensartinib
PF-03671148
CEP-37440
Etalocib
GW6604
CEP-14083
CEP-14513
A-83-01
SB-505124 hydrochloride hydrate
NVP-TAE684
目录项下的产品
1022958-60-6 / MFCD122958606
CEP-28122
原料
0
资源
0.0
询
0.0
%成交
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试剂
1097917-15-1 / MFCD197917151
N2-(2-(Isopropylsulfonyl)Phenyl)-N4-(2-Methoxy-4-(4-(4-Methylpiperazin-1-Yl)Piperidin-1-Yl)Phenyl)-1,3,5-Triazine-2,4-Diamine
N2-(2-(异丙基磺酰基)苯基)-N4-(2-甲氧基-4-(4-(4-甲基哌嗪-1-基)哌啶-1-基)苯基)-1,3,5-三嗪-2,4-二胺
原料
0
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0.0
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0.0
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试剂
1108743-60-7 / MFCD208743607
N-(5-(3,5-Difluorobenzyl)-1H-Indazol-3-Yl)-4-(4-Methylpiperazin-1-Yl)-2-((Tetrahydro-2H-Pyran-4-Yl)Amino)Benzamide
N-(5-(3,5-二氟苄基)-1H-吲唑-3-基)-4-(4-甲基哌嗪-1-基)-2-((四氢-2H-吡喃-4-基)氨基)苯甲酰胺
原料
0
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0.0
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0.0
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中华人民共和国
1116235-97-2 / MFCD216235972
GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and IR (insulin receptor) with IC50s of 2.0 and 1.6 nM, respectively . GSK1838705A blocks the in vitro proliferation of cell lines derived from solid and hematologic malignancies, including multiple myeloma and Ewing's sarcoma, and retards the growth of human tumor xenografts in vivo. Despite the inhibitory effect of GSK1838705A on insulin receptor, minimal effects on glucose homeostasis were observed at efficacious doses. GSK1838705A also inhibits the anaplastic lymphoma kinase (ALK), which drives the aberrant growth of anaplastic large-cell lymphomas, some neuroblastomas, and a subset of non-small cell lung cancers. GSK1838705A inhibits ALK, with an IC(50) of 0.5 nmol/L, and causes complete regression of ALK-dependent tumors in vivo at well-tolerated doses. GSK1838705A is therefore a promising antitumor agent for therapeutic use in human cancers. (source: Mol Cancer Ther. 2009 Oct;8(10):2811-20. ).
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0
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0.0
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0.0
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试剂
1356962-20-3 / MFCD456962203
N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
N-(4-(4-氨基哌啶-1-基)-2-甲氧基苯基)-5-氯-4-(1H-吲哚-3-基)嘧啶-2-胺
原料
0
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0.0
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0.0
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试剂
1370651-20-9 / MFCD470651209
Ensartinib
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0
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0.0
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0.0
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中华人民共和国
1378524-25-4 / MFCD478524254
PF-03671148
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0
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0.0
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0.0
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1391712-60-9 / MFCD491712609
CEP-37440
(S)-2-((5-氯-2-((6-(4-(2-羟乙基)哌嗪-1-基)-1-甲氧基-6,7,8,9-四氢-5H-苯并[7]轮烯-2-基)氨基)嘧啶-4-基)氨基)-N-甲基苯甲酰胺
原料
0
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0.0
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0.0
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试剂
161172-51-6 / MFCD61172516
2-(3-(3-((5-Ethyl-4'-Fluoro-2-Hydroxy-[1,1'-Biphenyl]-4-Yl)Oxy)Propoxy)-2-Propylphenoxy)Benzoic Acid
2-(3-(3-((5-乙基-4'-氟-2-羟基-[1,1'-联苯]-4-基)氧基)丙氧基)-2-丙基苯氧基)苯甲酸
原料
0
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0.0
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0.0
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试剂
452342-37-9 / MFCD52342379
GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity. GW6604 is also a TGF-beta signaling pathway inhibitor. In vitro, GW6604 inhibited autophosphorylation of ALK5 with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW6604 reduced by 80% the expression of collagen IA1. Inhibition of ALK5 could be an attractive new approach to treatment of liver fibrotic diseases by both preventing matrix deposition and promoting hepatocyte regeneration. ( Br J Pharmacol. 2005 May;145(2):166-77. ).
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0.0
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856692-39-2 / MFCD56692392
CEP-14083 is a potent ALK inhibitor that has shown activity in an NPM/ALK–carrying T-cell lymphoma in vitro study. Presumably, this compound binds to the hinge region of the kinase in an ATP-competitive manner. CEP-14083 displays a potent activity against ALK in enzymatic assays (IC50 = 11 nmol/L). Further, CEP-14083 is also able to inhibit the insulin receptor at a concentration within a nanomolar range. In a preclinical assay, CEP-14083 showed that, via NPM/ALK TK inhibition, it could control the expression of molecules that determine T-cell identity and signaling in lymphoma cells. CEP-14083 has shown preclinical activity in both cell lines and animal models harboring ALK alteration.
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0
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0.0
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0.0
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856693-04-4 / MFCD56693044
CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM).
原料
0
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0.0
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0.0
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909910-43-6 / MFCD08705403
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺
原料
0
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0.0
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0.0
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中华人民共和国
694433-59-5 / MFCD11045901
SB-505124
SB-505124
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0
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0.0
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0.0
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中华人民共和国
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761439-42-3 / MFCD11977634
5-Chloro-N4-(2-(Isopropylsulfonyl)Phenyl)-N2-(2-Methoxy-4-(4-(4-Methylpiperazin-1-Yl)Piperidin-1-Yl)Phenyl)Pyrimidine-2,4-Diamine
5-氯-N2-[2-甲氧基-4-[4-(4-甲基-1-哌嗪基)-1-哌啶基]苯基]-N4-[2-[(1-甲基乙基)磺酰基]苯基]-2,4-嘧啶二胺
原料
0
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0.0
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0.0
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中华人民共和国
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