3-Aminobenzo[E][1,2,4]Triazine 1,4-Dioxide 3-氨基苯并[e][1,2,4]三嗪1,4-二氧化物

CAS 27314-97-2 MFCD00132954

化学结构图

27314-97-2
SMILES: NC1N=[N+]([O-])C2C=CC=CC=2[N+]=1[O-]

化学属性

Mol. FormulaC7H6N4O2
Mol. Weight178

别名和识别编码

Chemical Name3-Aminobenzo[E][1,2,4]Triazine 1,4-Dioxide
CAS Number27314-97-2
Synonym 1,2,4-Benzotriazin-3-amine 1,4-Dioxide 1,2,4-Benzotriazin-3-amine, 1,4-dioxide 3-Amino-1,2,4-benzotriazine-1,4-dioxide 4-Hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine SR 259075 SR 4233 SR-4233 TPZ 替拉扎明 Tirapazamine Tirazone WIN 59075 Win 59075
MDL NumberMFCD00132954
Chemical Name Translation3-氨基苯并[e][1,2,4]三嗪1,4-二氧化物
Beilstein Registry Number0179322
PubChem Substance ID329825548
LabNetwork Molecule IDLN01282551
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • {SNA} Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, DNA Intercalators and Crosslinkers, DNA metabolism, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Heterocycles
  • Amines
  • Intermediates & Fine Chemicals,

产品应用

  • A bioreductive anticancer agent. Selectively toxic to cells under hypoxic conditions. An antineoplastic.

相关文献及参考

  • Brown, J.M.: Brit. J. Cancer, 67, 1163 (1993),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSDM0671500
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 89 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IOBPD3 International Journal of Radiation Oncology, Biology, Physics.
   (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
      1975-  Volume(issue)/page/year: 16,977,1989

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >36 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Endocrine - other changes
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 12,154,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 59390 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   66,100,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 101 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   BJCSB5 British Journal of Cancer, Supplement.  (Macmillan Press Ltd.,
   Houndmills

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 500 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 11,1407,1990

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 500 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 11,1407,1990

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Mammary gland
DOSE/DURATION           : 500 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 11,1407,1990

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Triazines 三嗪

相关产品推荐