Amprotropine

CAS 134-53-2 MFCD00134532

化学结构图

134-53-2
SMILES: CCN(CC)CC(C)(C)COC(=O)C(CO)c1ccccc1.O=P(O)(O)O

化学属性

Mol. Weight405.48
Mol. FormulaC18H29NO3.H3O4P

别名和识别编码

Chemical NameTropic acid, 3-(diethylamino)-2,2-dimethylpropylester, phosphate (1:1)
Chemicalbook IDCB31178022
Wiswesser Line NotationQ1YR&VO1X1&1&1N2&2 &P-O4
Synonym 3-Diethylamino-2,2-dimethylpropyl tropate phospate 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, tropate, phosphate d,l-Tropasaeureester des 3-diaethylamino-2,2-dimethyl-1-propanol phosphat Amprotropine phosphate AP 407 Syntropan
CAS Number134-53-2
PubChem Substance ID8644
InChIInChI=1S/C18H29NO3.H3O4P/c1-5-19(6-2)13-18(3,4)14-22-17(21)16(12-20)15-10-8-7-9-11-15;1-5(2,3)4/h7-11,16,20H,5-6,12-14H2,1-4H3;(H3,1,2,3,4)
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安全信息

RTECSYM8400000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 173,86,1933

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 30

TYPE OF TEST            : LDLo - Lowest published lethal

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428

系列性分类

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