2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride 盐酸阿可乐定(曾用名:盐酸安普乐定)

CAS 73218-79-8 MFCD00135922

化学结构图

73218-79-8
SMILES: NC1=CC(Cl)=C(N=C2NCCN2)C(Cl)=C1

化学属性

Mol. Weight281.59
Mol. FormulaC9H10Cl2N4.ClH

别名和识别编码

CAS Number73218-79-8
Chemical Name2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride
Synonym AL 02145 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine Hydrochloride Iopidine ALO-2145 Apraclonidine hydrochloride p-Aminoclonidine Monohydrochloride 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine hydrochloride p-Aminoclonidine hydrochloride ALO 2145
Chemical Name Translation盐酸阿可乐定(曾用名:盐酸安普乐定)
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Bases & Related Reagents,

产品应用

  • ?-Adrenergic agonist; structural analog of clonidine. Used for treatment of post-surgical elevated intraocular pressure.

相关文献及参考

  • Stump, D.C., et al.: J. Lab. Clin. Med., 102, 779 (1983),
  • Abrams, D.A., et al.: Arch. Ophthalmol., 105, 1205 (1987),
  • Robin, A.L., et al.: Am. J. Ophthalmol., 120, 423 (1995),

安全信息

RTECSCZ1582000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988

系列性分类

相关产品推荐