Urea,3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-, maleate (1:1)
CAS 19875-60-6 MFCD00153824
化学结构图
SMILES: CN1C[C@H](C=C2[C@H]1CC1=CNC3C=CC=C2C1=3)NC(=O)N(CC)CC.OC(=O)/C=C/C(O)=O
化学属性
| Mol. Formula | C20H26N4O.C4H4O4 |
|---|---|
| Mol. Weight | 454.58 |
别名和识别编码
| Chemical Name | Urea,3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-, maleate (1:1) |
|---|---|
| Wiswesser Line Notation | T C6656 1A P GN LM CUTT&&J EMVN2&2 G1 &QV1U1VQ |
| Synonym | Cuvalit 3-(9,10-Didehydro-6-methylergolin-8-yl)-1,1-diethylurea hydrogen maleate 3-(9,10-Didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylurea maleate |
| CAS Number | 19875-60-6 |
| Chemical Name Translation |
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安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 714 ng/kg TOXIC EFFECTS : Behavioral - headache Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year:
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 1429 ng/kg/3M-C TOXIC EFFECTS : Cardiac - other changes Gastrointestinal - nausea or vomiting Skin and Appendages - sweating REFERENCE : CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park Ridge, IL 60068) V.57- 1970- Volume(issue)/page/year: 91,792,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12200 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 15,1165,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 123 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 15,1165,19
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 350 mg/kg SEX/DURATION : male 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowp
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 600 ug/kg SEX/DURATION : female 6 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - breasts, lactation (prior to or during pregnancy) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 10,2593,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 18 mg/kg SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 50 ug/kg SEX/DURATION : lactating female 5 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - postpartum REFERENCE : ENEXAM Endocrinologia Experimentalis. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.1- 1964- Volume(issue)/page/year: 8,51,1974
TYPE OF TEST : TDLo - Lowest published
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