Vincaleukoblastine, 3-(aminocarbonyl)-O(sup4)-deacetyl-3-de(methoxycarbonyl)-

CAS 53643-48-4 MFCD01675265

化学结构图

53643-48-4
SMILES: CN1[C@@H]2[C@]3(CCN4CC=C[C@](CC)([C@@H]34)[C@@H](O)[C@]2(O)C(N)=O)C2C=C(C(=CC1=2)OC)[C@]1(C[C@H]2C[C@](O)(C[N@](C2)CCC2=C1NC1C=CC=CC2=1)CC)C(=O)OC

化学属性

Mol. FormulaC43H55N5O7
Mol. Weight754.03

别名和识别编码

Chemical NameVincaleukoblastine, 3-(aminocarbonyl)-O(sup4)-deacetyl-3-de(methoxycarbonyl)-
Synonym 3-(Aminocarbonyl)-O(sup
CAS Number53643-48-4
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安全信息

RTECSYY8080000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1213,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13800 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 28,1079,1985

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 1100 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 174,11,1986

系列性分类

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