Vindesine sulfate salt hydrate 硫酸长春地辛

CAS 59917-39-4 MFCD01675266

化学结构图

59917-39-4
SMILES: CN1[C@@H]2[C@]3(CCN4CC=C[C@](CC)([C@@H]34)[C@@H](O)[C@]2(O)C(N)=O)C2C=C(C(=CC1=2)OC)[C@]1(C[C@H]2C[C@](O)(C[N@](C2)CCC2=C1NC1C=CC=CC2=1)CC)C(=O)OC.OS(O)(=O)=O |&1:2,3,10,13,14,16,29,31,33,36|

化学属性

Mol. FormulaC43H55N5O7· H2SO4· xH2O
Mol. Weight852.00 (anhydrous basis)

别名和识别编码

Chemical NameVindesine sulfate salt hydrate
CAS Number59917-39-4 (anhydrous)
Synonym 23-Amino-O(sup 4)-deacetyl-23-demethoxyvincaleukoblastine sulfate 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate salt hydrate 3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate 4-Desacetilvinblastina-C-3-carboxamida sulfato DAVA Desacetylvinblastine amide sulfate Desacetylvinblastine amide sulfate salt hydrate Eldesine Eldisine Fildesin LY-099094 Lilly 99094 Vincaleukoblastine, 23-amino-O(sup 4)-deacetyl-23-demethoxy-, sulfate Vindesina sulfato Vindesine sulfate
PubChem Substance ID329829055
LabNetwork Molecule IDLN00364208
Chemical Name Translation硫酸长春地辛
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分类

  • Pharmaceuticals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Eli Lilly, V, 生物活性小分子, 细胞生物学
  • Intermediates & Fine Chemicals,

产品应用

  • Synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. Antineoplastic.

相关文献及参考

  • Todd, G.C., et al.: Toxicol. Environ. Health 1, 843 (1976),
  • Owellen, J.R., et al.: Biochem. Pharmacol., 26, 1213 (1977),

安全信息

RTECSYY8090000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 17,1549,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 1,843,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1790 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 17,1549,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1920 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - urine volume increased
   Blood - normocytic anemia
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 28 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,2886,1978

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 250 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 388,1,1997

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 50,311,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ug/kg
SEX/DURATION            : male 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 17,1859,1983

系列性分类

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