Urea, 1-methyl-1-nitroso-3-phenyl-

CAS 21561-99-9 MFCD01675908

化学结构图

21561-99-9
SMILES: CN(N=O)C(=O)NC1C=CC=CC=1

化学属性

Mol. FormulaC8H9N3O2
Mol. Weight179.20

别名和识别编码

Chemical NameUrea, 1-methyl-1-nitroso-3-phenyl-
Wiswesser Line NotationONN1&VMR
Synonym 3-Phenyl-1-methyl-1-nitrosoharnstoff Methylphenylnitrosourea Nitrosomethylphenylurea 1-Methyl-1-nitroso-3-phenylurea MPNU N-Methyl-N'-phenyl-N-nitrosourea Urea, N-methyl-N-nitroso-N'-phenyl- N-Methyl-N-nitroso-N'-phenylurea
Beilstein Registry Number2806200
CAS Number21561-99-9
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 750 mg/kg/32W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   4,299,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   MVMZA8 Monatshefte fuer Veterinaermedizin.  (VEB Gustav Fischer Verlag,
   Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 33,128,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 532 mg/kg/7W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,1027,1984

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   MVMZA8 Monatshefte fuer Veterinaermedizin.  (VEB Gustav Fischer Verlag,
   Postfach 176, Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 33,

RTECSYT8100000 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33500 pmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,5147,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 10 umol/L
REFERENCE :
   IAPUDO IARC Publications.  (WHO Publications Centre USA, 49 Sheridan Ave.,
   Albany, NY 12210) No.27-    1979-  Volume(issue)/page/year: 31,797,1980

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 10 umol/L
REFERENCE :
   IAPUDO IARC Publications.  (WHO Publications Centre USA, 49 Sheridan Ave.,
   Albany, NY 12210) No.27-    1979-  Volume(issue)/page/year: 31,797,1980

系列性分类

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