1-alpha-H,5-alpha-H-Tropanium,3-alpha-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)- 8-methyl-, bromide

CAS 10139-98-7 MFCD01677500

化学结构图

10139-98-7
SMILES: [Br-].C[N+]1(C)[C@@H]2C[C@H](C[C@H]1CC2)OC1C2C=CC=CC=2CCC2C=CC=CC=21 |&1:4,6,8|

化学属性

Mol. FormulaC24H30NO.Br
Mol. Weight428.46

别名和识别编码

Chemical Name1-alpha-H,5-alpha-H-Tropanium,3-alpha-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)- 8-methyl-, bromide
Wiswesser Line NotationL C676&T&J BO- GT56 A AKTJ A1 A1 &E
Synonym 3-alpha-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-8-methyltropanium bromide Deptropine methobromide BS 7020a
CAS Number10139-98-7
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安全信息

RTECSYM3575000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 192,105,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pint

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1150 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 192,105,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 71 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - aggression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 192,105,1971

系列性分类

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