3H-1,2,4-Triazol-3-one,2,4-dihydro-2-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-4,5- diethyl-, hydrochloride

CAS 57775-22-1 MFCD01678245

化学结构图

57775-22-1
SMILES: Cl.CCN1C(=O)N(CCCN2CCN(CC2)C2C=C(Cl)C=CC=2)N=C1CC

化学属性

Mol. FormulaC19H28ClN5O.ClH
Mol. Weight414.43

别名和识别编码

Chemical Name3H-1,2,4-Triazol-3-one,2,4-dihydro-2-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-4,5- diethyl-, hydrochloride
CAS Number57775-22-1
Synonym Etoperidone hydrochloride Staff Axiomin Tropene Etoperidone Clopradone, trazolinone AF-1191 AF 1191 Deprecer Etoperidona ST-1191 Depracer 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one Hydrochloride ST 1191 Etonin McN-A 2673-11 Etoran
Wiswesser Line NotationT5NNVNJ D2 E2 B3- AT6N DNTJ DR CG &GH
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A psychotropic drug related structurally to trazodone. Antidepressant.

相关文献及参考

  • Barcellona, S., et al.: Toxicology, 8, 87 (1977),
  • Bertoletti, G., et al.: Clin. Med., 58, 393 (1977),
  • Lisciani, R., et al.: Arzneim.-Forsch., 28, 417 (1978),

安全信息

RTECSXZ5483000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 29,294,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 397 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 29,294,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,417,1978

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-79

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 8,87,1977

系列性分类

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