2H-1,3,2-Oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-5-fluoro-,2-oxide, (E)-
CAS 78542-60-6 MFCD01710209
化学结构图
SMILES: O=P1(NCC(F)CO1)N(CCCl)CCCl
化学属性
| Mol. Formula | C7H14Cl2FN2O2P |
|---|---|
| Mol. Weight | 279.10 |
别名和识别编码
| Chemical Name | 2H-1,3,2-Oxazaphosphorine,tetrahydro-2-(bis(2-chloroethyl)amino)-5-fluoro-,2-oxide, (E)- |
|---|---|
| Synonym | trans-5-Fluorocyclophosphamide trans-2-(Bis(2-chloroethyl)amino)-5-fluorotetrahydro-2H-1,3,2-oxazaphosphorine |
| CAS Number | 78542-60-6 |
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TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,1399,1981
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