Luteinizing hormone-releasing factor (pig),6-D-tryptophan-7-(N-methyl-L-leucine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-

CAS 66866-63-5 MFCD01716219

化学结构图

66866-63-5
SMILES: CN([C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC)C(=O)[C@@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2C=CC=CC=21)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1

化学属性

Mol. FormulaC65H85N17O12
Mol. Weight1296.67

别名和识别编码

Chemical NameLuteinizing hormone-releasing factor (pig),6-D-tryptophan-7-(N-methyl-L-leucine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-
Synonym Wyeth 40972 WY 40,972 D-Trp(sup 6)-(N)Me-leu(sup 7)-des-gly(sup 10)-pro(sup 9)-LHRH ethylamide Lutrelin
CAS Number66866-63-5
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安全信息

RTECSOK6750000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AEFTAA Acta Europaea Fertilitatis.  (COFESE Eds., Piazzale Ungheria 73,
   90141 Palermo, Italy) V.1-    1969-  Volume(issue)/page/year: 11,113,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 70 ug/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   IJGOAL International Journal of Gynaecology & Obstetrics.  (Elsevier
   Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland)  V.7-    1969-
   Volume(issue)/page/year: 16,359,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 250 ug/kg
SEX/DURATION            : female 6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   INJFA3 International Journal of Fertility.  (Allen Press, 1041 New
   Hampshire,  St., Lawrence, KS 66044)  V.1-    1955- Volume(issue)/page/year:
   29,122,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   IJGOAL International Journal of Gynaecology & Obstetrics.  (Elsevier
   Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland)  V.7-    1969-
   Volume(issue)/page/year: 16,359,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE

系列性分类

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