(1H-Indol-5-yl)methanamine 5-(氨基甲基)吲哚

CAS 81881-74-5 MFCD01719220

化学结构图

81881-74-5
SMILES: NCC1=CC2C=CNC=2C=C1

化学属性

Mol. FormulaC9H10N2
Mol. Weight146.19
Melting Point114-122 °C

别名和识别编码

Chemical Name(1H-Indol-5-yl)methanamine
CAS Number81881-74-5
Synonym (1H-Indol-5-ylmethyl)amine 1H-Indole-5-methanamine Indole-5-methanamine 1-(1H-Indol-5-yl)methanamine 5-(氨基甲基)吲哚 5-Aminomethyl indole ((Indol-5-yl)methyl)amine
MDL NumberMFCD01719220
PubChem Substance ID24884128
Chemical Name Translation5-(氨基甲基)吲哚
Wiswesser Line NotationT56 BMJ G1Z
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分类

  • {SNA} Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles
  • Inhibitors
  • Heterocycles
  • Pharmaceuticals
  • Amines
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • 5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of ?-aminobutyric acid aminotransferase (GABA-AT) inhibitors.

相关文献及参考

  • Yuan, H., et al.: Bioorg. Med. Chem., 14,?1331 (2006),

安全信息

Hazard Codes Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSNL4461500
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#12077

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indolines 吲哚啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  5. C7 to C9 - Indoles

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