Cilastatin 西司他丁

CAS 82009-34-5 MFCD01723686

化学结构图

82009-34-5
SMILES: CC1(C)C[C@H]1C(=O)N/C(=C\CCCCSC[C@@H](N)C(O)=O)/C(O)=O

化学属性

Mol. FormulaC16H26N2O5S
Mol. Weight358.50

别名和识别编码

Chemical NameCilastatin
CAS Number82009-34-5
Synonym Cilastatin (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid MK-791
Chemical Name Translation西司他丁
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分类

  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.

相关文献及参考

  • Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983),
  • Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983),

安全信息

RTECSMJ9650100 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHINDQ Pharmacy International.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1980- Volume(issue)/page/year:
   5,133,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHINDQ Pharmacy International.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1980- Volume(issue)/page/year:
   5,133,1984

系列性分类

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