Bromazine Hydrochloride Bromodiphenhydramine

CAS 1808-12-4 MFCD01727165

化学结构图

1808-12-4
SMILES: CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1.Cl

化学属性

Mol. FormulaC17H21BrClNO
Mol. Weight371

别名和识别编码

Chemical Namehydrochloride United States Pharmacopeia (USP) Reference Standard Bromazine Hydrochloride
CAS Number1808-12-4
Synonym 2-(4-Bromodiphenylmethoxy)ethyldimethylamine Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-N,N-dimethyl-, hydrochloride 2-((p-Bromo-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride 4-Bromo-alpha-phenylbenzyl 2-dimethylaminoethyl ether 2-(4-Bromobenzohydryloxy)-ethyl-dimethylamine hydrochloride Bromazin beta-(p-Bromobenzhydryloxy)ethyldimethylamine hydrochloride Bromo-benzdryl ######## Bromodiphenhydramine hydrochloride Deserol Ambodryl hydrochloride Bromdiphenylhydramine hydrochloride
Chemical Name TranslationBromodiphenhydramine
Wiswesser Line NotationER DYR&O2N1&1 &GH
PubChem Substance ID519514
InChIInChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
MDL Number
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Antihistaminic.

相关文献及参考

  • Vespalec, R., et al.: Chem. Rev., 100, 3715 (2000),
  • Wang, W., et al.: Anal. Lett., 34, 569 (2001),
  • Scriba, G., et al.: J. Pharm. Biomed. Anal., 27, 373 (2002),

安全信息

RTECSKQ8420000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 602 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 366 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED

系列性分类

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