Toremifene Citrate 枸橼酸托瑞米芬

CAS 89778-27-8 MFCD01729016

化学结构图

89778-27-8
SMILES: CN(C)CCOC1C=CC(=CC=1)/C(=C(/CCCl)\C1C=CC=CC=1)/C1C=CC=CC=1.OC(=O)C(O)(CC(O)=O)CC(O)=O

化学属性

Mol. Weight598.08
Mol. FormulaC26H28ClNO · C6H8O7

别名和识别编码

CAS Number89778-27-8
Chemical NameToremifene Citrate
Synonym (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine Acapodene Fareston GTx 006 Z-Toremifene (Z)-4-Chloro-1,2-diphenyl-1-(4-(2-(N,N-dimethylamino)ethoxy)phenyl)-1-butene citrate (1:1) 2-(para-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine citrate (1:1) 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate FC 1157a Fareston NK 622 Toremifene citrate
PubChem Substance ID329826860
MDL NumberMFCD01729016
Chemical Name Translation枸橼酸托瑞米芬
LabNetwork Molecule IDLN00818291
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分类

  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Estrogen, Hormones, Steroid Hormones, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Amines
  • Aromatics

产品应用

  • An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to Tamoxifen.

相关文献及参考

  • Kallio, S., et al.: Cancer Chemother. Pharmacol., 17, 103 (1986),
  • Valavaara, R., et al.: Eur. J. Cancer Clin. Oncol., 24, 785 (1988),

安全信息

RTECSKH2156700 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Kidney, Ureter, Bladder - incontinence
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 44,351,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Kidney, Ureter, Bladder - incontinence
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 44,351,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 44,351,1992

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 35 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 17,1051,1996

GHS Symbol
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Hazard Codes Xn,N
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
Risk Statements
  • R50/53
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
WGK Germany3
Precautionary statements
  • P305+P351+P338+P310
  • P301+P312+P330
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger

系列性分类

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