Gemcitabine Hydrochloride 盐酸吉西他滨

CAS 122111-03-9 MFCD01735988

化学结构图

122111-03-9
SMILES: NC1C=CN([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)C(=O)N=1

化学属性

Mol. FormulaC9H11F2N3O4.HCl
Mol. Weight299.66
Refractive index268
Melting Point292

别名和识别编码

Chemical NameGemcitabine Hydrochloride
Synonym 2'-Deoxy-2',2'-difluorocytidine; dFdC Gemzar (Lilly) LY-188011 dFdC dFdCyd {uni_hamburg} 2’-deoxy-2’,2’-difluorocytidinemonohydrochloride DFDC GemcitabineHydrochloride&Int.; 2',2'-Difluoro-2'-deoxycytidine DDFC 2Deoxy-22difluorocytidine Hydrochloride, dFdC, dFdCyd, ly188011hydrochloride {Ch 4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1h-pyrimidin-2-one hydrochloride dizirconium silicide DDFC Zr2Si GEMCITABINE HYDROCHLORIDE GEMCITABINE HYDRECHLORIDE DFDCYD gemzar 2',2'-DIFLUORO-2'-DEOXYCYTIDINE Gemzar LY 188011 2’-deoxy-2’,2’-difluoro-cytidinmonohydrochloride 2′-Deoxy-2′,2′-difluorocytidine
MDL NumberMFCD01735988
Chemical Name Translation盐酸吉西他滨
CAS Number122111-03-9
Reaxys-RN5386970
PubChem Substance ID125307627
Merck Number4386
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分类

  • {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience, Eli Lilly, G
  • {uni_hamburg}
  • {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Eli Lilly, Fluorination Ready Pharma-Developed Compounds, G, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology,

相关文献及参考

  • Short: III/21e Title: Superconductors: Transition Temperatures and Characterization of Elements, Alloys and Compounds: Tl ... Zr Author: Flükinger, R.; Hulliger, F.; Luo, H.L.; Wolf, T.; Xu, J.Q. Editor: Flükiger, R.; Klose, W. Source: Landolt-Börnstein, New Series Volume: III/21e Year: 2002 Keyword: Landolt-Börnstein; Quantum Fluids; Superconductivity; Superfluidity ISBN: 3-540-56049-1 ISBN: 978-3-540-56049-4 Internet Resource: DOI:10.1007/b47748 RefComment: XXXI, 443 pages, with CD-ROM, Hardcover RefComment: Written for scientists and researchers in the fields of chemistry and physics Abstract: In volume III/21 a compilation is given of all reported experimental data on superconducting materials from the discovery of this phenomenon. The presented data include not only the superconducting properties related to a given material, but also the full metallurgical and crystallographical characterization. In addition to other low temperature physical properties, which are explicitly given in a particular column are presented. The substances are arranged alphabetically by the base element, i.e. that element with the highest concentration in an alloy or compound. Only original and critically reviewed experimental data are retained.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Safety Statements
GHS Symbol
WGK Germany3
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P302+P350
  • P337+P313
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P302+P352+P332+P313+P362+P364
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Signal word
Hazard Codes Xn
Risk Statements
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
RTECSHA3840000
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 15 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 48,365,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 15 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 48,365,1993

系列性分类


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