Colchicine, O(sup 2)-demethyl-10-thio-

CAS 87424-26-8 MFCD01736968

化学结构图

87424-26-8
SMILES: CC(=O)NC1CCC2C=C(OC)C(O)=C(OC)C=2C2=CC=C(SC)C(=O)C=C21

化学属性

Mol. FormulaC21H23NO5S
Mol. Weight401.51

别名和识别编码

Chemical NameColchicine, O(sup 2)-demethyl-10-thio-
CAS Number87424-26-8
Synonym 2-Demethylthiocolchicine NSC 369937 O(sup 2)-Demethyl-10-thiocolchicine N-[(7S)-5,6,7,9-Tetrahydro-2-hydroxy-1,3-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
Beilstein Registry Number3176298
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分类

  • Inhibitors,

产品应用

  • Has shown anti-tumor activity.

安全信息

RTECSGH0882000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 109,386,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 109,386,1957

系列性分类

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